Version history

{
  "scope": "mouse S1 C2 barrel column, paired whole-cell recordings, all layers",
  "claim_text": "Quantitative paired-whole-cell mapping of the mouse C2 barrel column reveals strong layer-specific excitatory connectivity between pyramidal/spiny neurons: connection probability and amplitude depend on the laminar identity of both pre- and postsynaptic neurons, with presynaptic L4 neurons exerting the strongest excitatory influence on the column and rare large-amplitude E→E connections present in every layer.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuron.2008.12.020",
    "claim": "Quantitative paired-whole-cell mapping of the mouse C2 barrel column reveals strong layer-specific excitatory connectivity between pyramidal/spiny neurons: connection probability and amplitude depend on the laminar identity of both pre- and postsynaptic neurons, with presynaptic L4 neurons exerting the strongest excitatory influence on the column and rare large-amplitude E→E connections present in every layer.",
    "cite_key": "Lefort2009",
    "evidence": "Multiple simultaneous whole-cell recordings between excitatory neurons across all layers of the anatomically delineated C2 barrel column in mouse S1 brain slices; connection probability and amplitude tabulated per laminar pair.",
    "effect_size": "Presynaptic L4 provides the strongest excitatory drive on the column; rare large-amplitude E→E connections detected in all layers",
    "text_access": "abstract_only",
    "study_system": "mouse S1 C2 barrel column, paired whole-cell recordings, all layers",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Synaptic connectivity depended strongly upon somatic laminar location of both presynaptic and postsynaptic neurons, providing definitive evidence for layer-specific signaling pathways.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1093/cercor/bhx094"
    ],
    "effect_size_source_sentence": "The strongest excitatory influence upon the cortical column was provided by presynaptic layer 4 neurons. In all layers we found rare large-amplitude synaptic connections, which are likely to contribute strongly to reliable information processing."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "Presynaptic L4 provides the strongest excitatory drive on the column; rare large-amplitude E→E connections detected in all layers",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-bdc020492b80"
  ],
  "source_span": "Synaptic connectivity depended strongly upon somatic laminar location of both presynaptic and postsynaptic neurons, providing definitive evidence for layer-specific signaling pathways.",
  "study_system": "mouse S1 C2 barrel column, paired whole-cell recordings, all layers",
  "evidence_refs": [
    {
      "ref": "paper:paper-bdc020492b80"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Multiple simultaneous whole-cell recordings between excitatory neurons across all layers of the anatomically delineated C2 barrel column in mouse S1 brain slices; connection probability and amplitude tabulated per laminar pair.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}