Quantitative paired-whole-cell mapping of the mouse C2 barrel column reveals st…

Quantitative paired-whole-cell mapping of the mouse C2 barrel column reveals strong layer-specific excitatory connectivity between pyramidal/spiny neurons: connection probability and amplitude depend on the laminar identity of both pre- and postsynaptic neurons, with presynaptic L4 neurons exerting the strongest excitatory influence on the column and rare large-amplitude E→E connections present in every layer.

{
  "n": 0,
  "doi": "10.1016/j.neuron.2008.12.020",
  "claim": "Quantitative paired-whole-cell mapping of the mouse C2 barrel column reveals strong layer-specific excitatory connectivity between pyramidal/spiny neurons: connection probability and amplitude depend on the laminar identity of both pre- and postsynaptic neurons, with presynaptic L4 neurons exerting the strongest excitatory influence on the column and rare large-amplitude E→E connections present in every layer.",
  "cite_key": "Lefort2009",
  "evidence": "Multiple simultaneous whole-cell recordings between excitatory neurons across all layers of the anatomically delineated C2 barrel column in mouse S1 brain slices; connection probability and amplitude tabulated per laminar pair.",
  "effect_size": "Presynaptic L4 provides the strongest excitatory drive on the column; rare large-amplitude E→E connections detected in all layers",
  "text_access": "abstract_only",
  "study_system": "mouse S1 C2 barrel column, paired whole-cell recordings, all layers",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Synaptic connectivity depended strongly upon somatic laminar location of both presynaptic and postsynaptic neurons, providing definitive evidence for layer-specific signaling pathways.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1093/cercor/bhx094"
  ],
  "effect_size_source_sentence": "The strongest excitatory influence upon the cortical column was provided by presynaptic layer 4 neurons. In all layers we found rare large-amplitude synaptic connections, which are likely to contribute strongly to reliable information processing."
}

[
  "paper:paper-bdc020492b80"
]

[
  {
    "ref": "paper:paper-bdc020492b80"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}