Mouse V1 prediction-error signals are generated by a cooperative thalamocortica…

Mouse V1 prediction-error signals are generated by a cooperative thalamocortical disinhibitory circuit: violating predictions with unexpected visual stimuli preferentially boosts responses of L2/3 V1 neurons most selective for that stimulus, demonstrating that prediction errors specifically amplify the unexpected input (rather than generating non-specific surprise signals) — implemented by a circuit involving cortically driven thalamic input and local disinhibition.

{
  "n": 0,
  "doi": "10.1038/s41586-024-07851-w",
  "claim": "Mouse V1 prediction-error signals are generated by a cooperative thalamocortical disinhibitory circuit: violating predictions with unexpected visual stimuli preferentially boosts responses of L2/3 V1 neurons most selective for that stimulus, demonstrating that prediction errors specifically amplify the unexpected input (rather than generating non-specific surprise signals) — implemented by a circuit involving cortically driven thalamic input and local disinhibition.",
  "cite_key": "Furutachi2024",
  "evidence": "Two-photon Ca²⁺ imaging + cell-type-specific optogenetic perturbations of mouse V1 L2/3 plus pulvinar thalamic input during prediction-error paradigm.",
  "effect_size": "qualitative — selective amplification of expected-stimulus-tuned neurons by thalamocortical disinhibition",
  "text_access": "fulltext",
  "study_system": "awake mouse V1 L2/3 plus pulvinar thalamic input during visual prediction-error task",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "violating animals' predictions by an unexpected visual stimulus preferentially boosts responses of the layer 2/3 V1 neurons that are most selective for that stimulus. Prediction errors specifically amplify the unexpected visual input, rather than representing non-specific surprise or difference signals",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Prediction errors specifically amplify the unexpected visual input"
}

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]

violating animals' predictions by an unexpected visual stimulus preferentially boosts responses of the layer 2/3 V1 neurons that are most selective for that stimulus. Prediction errors specifically amplify the unexpected visual input, rather than representing non-specific surprise or difference signals

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