Version history

{
  "scope": "mouse neocortex (VISp and ALM), single-cell RNA-seq with retrograde labelling",
  "claim_text": "Most glutamatergic neuron transcriptomic types in mouse neocortex are area-specific rather than shared between VISp and ALM, with only five shared types (one L6 CT, three L6b, and CR), correlating with their distinct long-range projection targets.",
  "raw_fields": {
    "n": 23822,
    "doi": "10.1038/s41586-018-0654-5",
    "claim": "Most glutamatergic neuron transcriptomic types in mouse neocortex are area-specific rather than shared between VISp and ALM, with only five shared types (one L6 CT, three L6b, and CR), correlating with their distinct long-range projection targets.",
    "cite_key": "Tasic2018",
    "evidence": "Single-cell RNA sequencing of 23,822 cells from VISp and ALM combined with retrograde labelling of 2,204 cells to match transcriptomic types to projection specificity.",
    "effect_size": "Best-matched area-specific glutamatergic types have a median of 78 differentially expressed genes with average eightfold difference in expression, versus shared GABAergic types with median of 2 differentially expressed genes and 5.2-fold difference",
    "text_access": "fulltext",
    "study_system": "mouse neocortex (VISp and ALM), single-cell RNA-seq with retrograde labelling",
    "argument_role": "supporting",
    "replication_status": "novel",
    "claim_source_sentence": "Most glutamatergic types are area-specific. By contrast, and as previously suggested, non-neuronal and most GABAergic neuronal types are shared across cortical areas.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "We find that the best-matched glutamatergic types have a median of 78 differentially expressed genes and average eightfold difference in expression (,)."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "Best-matched area-specific glutamatergic types have a median of 78 differentially expressed genes with average eightfold difference in expression, versus shared GABAergic types with median of 2 differentially expressed genes and 5.2-fold difference",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-pm-30382198"
  ],
  "source_span": "Most glutamatergic types are area-specific. By contrast, and as previously suggested, non-neuronal and most GABAergic neuronal types are shared across cortical areas.",
  "study_system": "mouse neocortex (VISp and ALM), single-cell RNA-seq with retrograde labelling",
  "evidence_refs": [
    {
      "ref": "paper:paper-pm-30382198"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Single-cell RNA sequencing of 23,822 cells from VISp and ALM combined with retrograde labelling of 2,204 cells to match transcriptomic types to projection specificity.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "novel",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}