Most glutamatergic neuron transcriptomic types in mouse neocortex are area-spec…

Most glutamatergic neuron transcriptomic types in mouse neocortex are area-specific rather than shared between VISp and ALM, with only five shared types (one L6 CT, three L6b, and CR), correlating with their distinct long-range projection targets.

{
  "n": 23822,
  "doi": "10.1038/s41586-018-0654-5",
  "claim": "Most glutamatergic neuron transcriptomic types in mouse neocortex are area-specific rather than shared between VISp and ALM, with only five shared types (one L6 CT, three L6b, and CR), correlating with their distinct long-range projection targets.",
  "cite_key": "Tasic2018",
  "evidence": "Single-cell RNA sequencing of 23,822 cells from VISp and ALM combined with retrograde labelling of 2,204 cells to match transcriptomic types to projection specificity.",
  "effect_size": "Best-matched area-specific glutamatergic types have a median of 78 differentially expressed genes with average eightfold difference in expression, versus shared GABAergic types with median of 2 differentially expressed genes and 5.2-fold difference",
  "text_access": "fulltext",
  "study_system": "mouse neocortex (VISp and ALM), single-cell RNA-seq with retrograde labelling",
  "argument_role": "supporting",
  "replication_status": "novel",
  "claim_source_sentence": "Most glutamatergic types are area-specific. By contrast, and as previously suggested, non-neuronal and most GABAergic neuronal types are shared across cortical areas.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "We find that the best-matched glutamatergic types have a median of 78 differentially expressed genes and average eightfold difference in expression (,)."
}

Best-matched area-specific glutamatergic types have a median of 78 differentially expressed genes with average eightfold difference in expression, versus shared GABAergic types with median of 2 differentially expressed genes and 5.2-fold difference

[
  "paper:paper-pm-30382198"
]

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