Version history

{
  "scope": "mouse, Dlx1/Dlx2 double knockout, embryonic telencephalon",
  "claim_text": "Loss of both DLX-1 and DLX-2 homeobox proteins eliminates detectable cell migration from the subcortical telencephalon into the developing neocortex and reduces neocortical GABA-expressing cells, providing the founding genetic evidence that cortical GABAergic interneurons originate subcortically and require Dlx genes for tangential migration.",
  "raw_fields": {
    "n": null,
    "doi": "10.1126/science.278.5337.474",
    "claim": "Loss of both DLX-1 and DLX-2 homeobox proteins eliminates detectable cell migration from the subcortical telencephalon into the developing neocortex and reduces neocortical GABA-expressing cells, providing the founding genetic evidence that cortical GABAergic interneurons originate subcortically and require Dlx genes for tangential migration.",
    "title": null,
    "cite_key": "Anderson1997",
    "evidence": "Dlx1/Dlx2 double-knockout mouse embryos; in vitro slice migration assays; GABA immunostaining in neocortical slices ± subcortical telencephalon attachment.",
    "effect_size": "Complete loss of subcortex→neocortex migration in Dlx1/2 dKO; large reduction in cortical GABA cells",
    "figure_data": [],
    "text_access": "abstract_only",
    "study_system": "mouse, Dlx1/Dlx2 double knockout, embryonic telencephalon",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "primary",
    "_source_cluster_index": 95,
    "claim_source_sentence": "Mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neocortex.",
    "replication_evidence_dois": [
      "10.1016/s0896-6273(00)80345-1"
    ],
    "effect_size_source_sentence": "Mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neocortex."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "Complete loss of subcortex→neocortex migration in Dlx1/2 dKO; large reduction in cortical GABA cells",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-c7d272addca8"
  ],
  "source_span": "Mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neocortex.",
  "study_system": "mouse, Dlx1/Dlx2 double knockout, embryonic telencephalon",
  "evidence_refs": [
    {
      "ref": "paper:paper-c7d272addca8"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Dlx1/Dlx2 double-knockout mouse embryos; in vitro slice migration assays; GABA immunostaining in neocortical slices ± subcortical telencephalon attachment.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "primary",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}