Loss of both DLX-1 and DLX-2 homeobox proteins eliminates detectable cell migra…

Loss of both DLX-1 and DLX-2 homeobox proteins eliminates detectable cell migration from the subcortical telencephalon into the developing neocortex and reduces neocortical GABA-expressing cells, providing the founding genetic evidence that cortical GABAergic interneurons originate subcortically and require Dlx genes for tangential migration.

{
  "n": null,
  "doi": "10.1126/science.278.5337.474",
  "claim": "Loss of both DLX-1 and DLX-2 homeobox proteins eliminates detectable cell migration from the subcortical telencephalon into the developing neocortex and reduces neocortical GABA-expressing cells, providing the founding genetic evidence that cortical GABAergic interneurons originate subcortically and require Dlx genes for tangential migration.",
  "title": null,
  "cite_key": "Anderson1997",
  "evidence": "Dlx1/Dlx2 double-knockout mouse embryos; in vitro slice migration assays; GABA immunostaining in neocortical slices ± subcortical telencephalon attachment.",
  "effect_size": "Complete loss of subcortex→neocortex migration in Dlx1/2 dKO; large reduction in cortical GABA cells",
  "figure_data": [],
  "text_access": "abstract_only",
  "study_system": "mouse, Dlx1/Dlx2 double knockout, embryonic telencephalon",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "primary",
  "_source_cluster_index": 95,
  "claim_source_sentence": "Mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neocortex.",
  "replication_evidence_dois": [
    "10.1016/s0896-6273(00)80345-1"
  ],
  "effect_size_source_sentence": "Mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neocortex."
}

[
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]

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