Version history

{
  "scope": "Mouse motor cortex; Tlx3-Cre + DREADD chemogenetics.",
  "claim_text": "Bilateral chemogenetic activation of Tlx3+ layer-5 intratelencephalic neurons in mouse motor cortex reduces spontaneous locomotor activity in the open field, demonstrating that cortico-cortical IT neurons exert a causal anti-motor influence consistent with their extensive cortico-cortical and cortico-striatal projection logic.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.nbd.2024.106755",
    "claim": "Bilateral chemogenetic activation of Tlx3+ layer-5 intratelencephalic neurons in mouse motor cortex reduces spontaneous locomotor activity in the open field, demonstrating that cortico-cortical IT neurons exert a causal anti-motor influence consistent with their extensive cortico-cortical and cortico-striatal projection logic.",
    "cite_key": "Atudorei2025",
    "evidence": "DREADD-based chemogenetic activation of Tlx3-Cre IT neurons bilaterally in mouse motor cortex; open-field locomotion quantified.",
    "effect_size": "Bilateral IT activation reduced open-field locomotion and increased freezing/immobility, replicated with two chemogenetic actuators.",
    "text_access": "abstract_only",
    "study_system": "Mouse motor cortex; Tlx3-Cre + DREADD chemogenetics.",
    "argument_role": "supporting",
    "replication_status": "not_yet",
    "claim_source_sentence": "Bilateral chemogenetic activation of intratelencephalic Tlx3 neurons in the mouse motor cortex reduced spontaneous locomotor activity in the open field.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "This anti-motor effect was achieved in separate experiments with either administration of two chemogenetic actuators, clozapine N-oxide and deschloroclozapine."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": "Bilateral IT activation reduced open-field locomotion and increased freezing/immobility, replicated with two chemogenetic actuators.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-c4e7f2a4e77a"
  ],
  "source_span": "Bilateral chemogenetic activation of intratelencephalic Tlx3 neurons in the mouse motor cortex reduced spontaneous locomotor activity in the open field.",
  "study_system": "Mouse motor cortex; Tlx3-Cre + DREADD chemogenetics.",
  "evidence_refs": [
    {
      "ref": "paper:paper-c4e7f2a4e77a"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "DREADD-based chemogenetic activation of Tlx3-Cre IT neurons bilaterally in mouse motor cortex; open-field locomotion quantified.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "not_yet",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}