Bilateral chemogenetic activation of Tlx3+ layer-5 intratelencephalic neurons i…

Bilateral chemogenetic activation of Tlx3+ layer-5 intratelencephalic neurons in mouse motor cortex reduces spontaneous locomotor activity in the open field, demonstrating that cortico-cortical IT neurons exert a causal anti-motor influence consistent with their extensive cortico-cortical and cortico-striatal projection logic.

{
  "n": null,
  "doi": "10.1016/j.nbd.2024.106755",
  "claim": "Bilateral chemogenetic activation of Tlx3+ layer-5 intratelencephalic neurons in mouse motor cortex reduces spontaneous locomotor activity in the open field, demonstrating that cortico-cortical IT neurons exert a causal anti-motor influence consistent with their extensive cortico-cortical and cortico-striatal projection logic.",
  "cite_key": "Atudorei2025",
  "evidence": "DREADD-based chemogenetic activation of Tlx3-Cre IT neurons bilaterally in mouse motor cortex; open-field locomotion quantified.",
  "effect_size": "Bilateral IT activation reduced open-field locomotion and increased freezing/immobility, replicated with two chemogenetic actuators.",
  "text_access": "abstract_only",
  "study_system": "Mouse motor cortex; Tlx3-Cre + DREADD chemogenetics.",
  "argument_role": "supporting",
  "replication_status": "not_yet",
  "claim_source_sentence": "Bilateral chemogenetic activation of intratelencephalic Tlx3 neurons in the mouse motor cortex reduced spontaneous locomotor activity in the open field.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "This anti-motor effect was achieved in separate experiments with either administration of two chemogenetic actuators, clozapine N-oxide and deschloroclozapine."
}

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