Version history

{
  "scope": "review of intersectional mouse cortex (He 2016)",
  "claim_text": "VIP/CR co-expressing interneurons show distinct intrinsic-physiology distributions: VIP/CR cells are *significantly enriched* in irregular-spiking bipolar phenotypes, whereas VIP/CCK co-expressing cells (small CCK basket cells) more often have multipolar/bitufted dendrites and a local axonal arbor — providing a molecular x intrinsic-physiology axis within the VIP class (CR+ irregular-bipolar vs. CCK+ adapting-multipolar).",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2016.06.033",
    "claim": "VIP/CR co-expressing interneurons show distinct intrinsic-physiology distributions: VIP/CR cells are *significantly enriched* in irregular-spiking bipolar phenotypes, whereas VIP/CCK co-expressing cells (small CCK basket cells) more often have multipolar/bitufted dendrites and a local axonal arbor — providing a molecular x intrinsic-physiology axis within the VIP class (CR+ irregular-bipolar vs. CCK+ adapting-multipolar).",
    "title": null,
    "cite_key": "Tremblay2016",
    "evidence": "intersectional Vip-flp x CR-cre patch (He 2016 in Tremblay 2016 review)",
    "effect_size": "VIP/CR enriched for irregular spiking; VIP/CCK enriched for multipolar/bitufted",
    "text_access": "fulltext",
    "study_system": "review of intersectional mouse cortex (He 2016)",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 89,
    "claim_source_sentence": "In fact, using intersectional Vip flp x CR cre mice, He et al., (He et al., 2016) found that VIP/CR cells were significantly enriched in irregular spiking bipolar neurons.",
    "replication_evidence_dois": [
      "10.1016/j.cell.2020.09.057",
      "10.1016/j.neuron.2018.10.009"
    ],
    "effect_size_source_sentence": "In contrast to Vip CR INs, Cck-expressing Vip INs tend to exhibit multipolar or bitufted dendrites, although bipolar cells can also be found."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "VIP/CR enriched for irregular spiking; VIP/CCK enriched for multipolar/bitufted",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-53c8505de50f"
  ],
  "source_span": "In fact, using intersectional Vip flp x CR cre mice, He et al., (He et al., 2016) found that VIP/CR cells were significantly enriched in irregular spiking bipolar neurons.",
  "study_system": "review of intersectional mouse cortex (He 2016)",
  "evidence_refs": [
    {
      "ref": "paper:paper-53c8505de50f"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "intersectional Vip-flp x CR-cre patch (He 2016 in Tremblay 2016 review)",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}