VIP/CR co-expressing interneurons show distinct intrinsic-physiology distributi…

VIP/CR co-expressing interneurons show distinct intrinsic-physiology distributions: VIP/CR cells are *significantly enriched* in irregular-spiking bipolar phenotypes, whereas VIP/CCK co-expressing cells (small CCK basket cells) more often have multipolar/bitufted dendrites and a local axonal arbor — providing a molecular x intrinsic-physiology axis within the VIP class (CR+ irregular-bipolar vs. CCK+ adapting-multipolar).

{
  "n": null,
  "doi": "10.1016/j.neuron.2016.06.033",
  "claim": "VIP/CR co-expressing interneurons show distinct intrinsic-physiology distributions: VIP/CR cells are *significantly enriched* in irregular-spiking bipolar phenotypes, whereas VIP/CCK co-expressing cells (small CCK basket cells) more often have multipolar/bitufted dendrites and a local axonal arbor — providing a molecular x intrinsic-physiology axis within the VIP class (CR+ irregular-bipolar vs. CCK+ adapting-multipolar).",
  "title": null,
  "cite_key": "Tremblay2016",
  "evidence": "intersectional Vip-flp x CR-cre patch (He 2016 in Tremblay 2016 review)",
  "effect_size": "VIP/CR enriched for irregular spiking; VIP/CCK enriched for multipolar/bitufted",
  "text_access": "fulltext",
  "study_system": "review of intersectional mouse cortex (He 2016)",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 89,
  "claim_source_sentence": "In fact, using intersectional Vip flp x CR cre mice, He et al., (He et al., 2016) found that VIP/CR cells were significantly enriched in irregular spiking bipolar neurons.",
  "replication_evidence_dois": [
    "10.1016/j.cell.2020.09.057",
    "10.1016/j.neuron.2018.10.009"
  ],
  "effect_size_source_sentence": "In contrast to Vip CR INs, Cck-expressing Vip INs tend to exhibit multipolar or bitufted dendrites, although bipolar cells can also be found."
}

[
  "paper:paper-53c8505de50f"
]

[
  {
    "ref": "paper:paper-53c8505de50f"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}