Here, we sought to determine whether higher order visual cortical areas laterom…

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scope: mouse; V1, visual cortex; whole-cell patch, optogenetics; Current biology : CB
claim_text: Here, we sought to determine whether higher order visual cortical areas lateromedial (LM), anterolateral (AL), posteromedial (PM), and anteromedial (AM) have specialized anatomical and physiological…
section_id: section_09
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
review_repo: ComputationalReviewRecurrence
section_ref: wiki_page:computationalreviewrecurrence-09-amplification-isn
source_kind: review_finding
source_path: evidence/section_09_evidence_package.json
study_system: mouse; V1, visual cortex; whole-cell patch, optogenetics; Current biology : CB
section_title: 9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation
review_bundle_ref: analysis_bundle:ab-d9c479db9be9
replication_status: single_study
review_package_ref: analysis_bundle:ab-d9c479db9be9
source_artifact_ref: wiki_page:computationalreviewrecurrence-09-amplification-isn
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
commit_sha: 79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence

Raw fields (7)

raw_fields

{
  "n": null,
  "doi": "10.1016/j.cub.2021.09.042",
  "claim": "Here, we sought to determine whether higher order visual cortical areas lateromedial (LM), anterolateral (AL), posteromedial (PM), and anteromedial (AM) have specialized anatomical and physiological…",
  "cite_key": "Li2021a",
  "evidence": "Cortical visual processing transforms features of the external world into increasingly complex and specialized neuronal representations. These transformations arise in part through target-specific routing of information; however, within-area computations may also contribute to area-specific function. Here, we sought to determine whether higher order visual cortical areas lateromedial (LM), anterolateral (AL), posteromedial (PM), and anteromedial (AM) have specialized anatomical and physiological...",
  "effect_size": "In addition, we find that despite a lack of an overall difference in PV cell density across areas, there are some significant differences when separating by layers: PV cells in L6 are significantly more dense in AM compared to LM and AL, and PV cells in L5 are significantly denser in LM and AL versus AM (PV: one-way ANOVA with post hoc Tukey tests; L5 p=0.049, LM vs PM p=0.044; L6 p=0.008; LM vs PM p=0.011, AL vs PM p=0.037; n=8 mice).",
  "text_access": "fulltext",
  "study_system": "mouse; V1, visual cortex; whole-cell patch, optogenetics; Current biology : CB",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "Here, we sought to determine whether higher order visual cortical areas lateromedial (LM), anterolateral (AL), posteromedial (PM), and anteromedial (AM) have specialized anatomical and physiological properties by using a combination of whole-cell recordings and optogenetic stimulation of primary visual cortex (V1) axons in&#xa0;vitro.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "claim_rewritten_from_source": true,
  "effect_size_source_sentence": "In addition, we find that despite a lack of an overall difference in PV cell density across areas, there are some significant differences when separating by layers: PV cells in L6 are significantly more dense in AM compared to LM and AL, and PV cells in L5 are significantly denser in LM and AL versus AM (PV: one-way ANOVA with post hoc Tukey tests; L5 p=0.049, LM vs PM p=0.044; L6 p=0.008; LM vs PM p=0.011, AL vs PM p=0.037; n=8 mice)."
}

effect_size

In addition, we find that despite a lack of an overall difference in PV cell density across areas, there are some significant differences when separating by layers: PV cells in L6 are significantly more dense in AM compared to LM and AL, and PV cells in L5 are significantly denser in LM and AL versus AM (PV: one-way ANOVA with post hoc Tukey tests; L5 p=0.049, LM vs PM p=0.044; L6 p=0.008; LM vs PM p=0.011, AL vs PM p=0.037; n=8 mice).

source_refs

[
  "paper:paper-21937e5a070f"
]

source_span

Here, we sought to determine whether higher order visual cortical areas lateromedial (LM), anterolateral (AL), posteromedial (PM), and anteromedial (AM) have specialized anatomical and physiological properties by using a combination of whole-cell recordings and optogenetic stimulation of primary visual cortex (V1) axons in&#xa0;vitro.

evidence_refs

[
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    "ref": "paper:paper-21937e5a070f"
  }
]

source_policy

{
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evidence_summary

Cortical visual processing transforms features of the external world into increasingly complex and specialized neuronal representations. These transformations arise in part through target-specific routing of information; however, within-area computations may also contribute to area-specific function. Here, we sought to determine whether higher order visual cortical areas lateromedial (LM), anterolateral (AL), posteromedial (PM), and anteromedial (AM) have specialized anatomical and physiological...

Here, we sought to determine whether higher order visual cortical areas laterom…

Details

Replication

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