- claim_text
Closure of the V1 critical period for OD plasticity depends on nogo-66 receptor (ngr1) specifically in L4 excitatory neurons: deletion of ngr1 in L4 — but not L2/3, L5, or L6 — keeps adult mice sensitive to brief MD via intracortical (not thalamocortical) disinhibition.
- raw_fields
{
"n": 0,
"doi": "10.1016/j.cub.2020.05.067",
"claim": "Closure of the V1 critical period for OD plasticity depends on nogo-66 receptor (ngr1) specifically in L4 excitatory neurons: deletion of ngr1 in L4 — but not L2/3, L5, or L6 — keeps adult mice sensitive to brief MD via intracortical (not thalamocortical) disinhibition.",
"cite_key": "Frantz2020",
"evidence": "Layer-specific conditional deletion of ngr1 showed L4-restricted requirement for critical-period closure; OD plasticity advanced faster in L4 than L2/3 or L5; AM-251 block in L2/3 did not impair L5 plasticity, arguing against canonical L4→L2/3→L5 propagation.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "Mouse V1 layer-specific ngr1 conditional knockout (in vivo MD)",
"argument_role": "supporting",
"replication_status": "replication_unknown",
"claim_source_sentence": "Deleting ngr1 in excitatory neurons in L4, but not in L2/3, L5, or L6, prevented closure of the critical period, and adult mice remained sensitive to brief monocular deprivation.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-c4c760105083"
]
- evidence_refs
[
{
"ref": "paper:paper-c4c760105083"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}- evidence_summary
Layer-specific conditional deletion of ngr1 showed L4-restricted requirement for critical-period closure; OD plasticity advanced faster in L4 than L2/3 or L5; AM-251 block in L2/3 did not impair L5 plasticity, arguing against canonical L4→L2/3→L5 propagation.