Version history

{
  "scope": "hippocampal CA1 spiking model with diverse SST interneuron subtypes",
  "claim_text": "A hippocampal CA1 model with subtype-specific somatostatin interneurons (OLM, bistratified, BC) shows that bistratified cells gate dendritic excitability of pyramidal cells.",
  "raw_fields": {
    "n": null,
    "id": "cluster_11_finding_126",
    "doi": "10.1101/2023.04.27.538511",
    "pmid": "",
    "year": "2023",
    "claim": "A hippocampal CA1 model with subtype-specific somatostatin interneurons (OLM, bistratified, BC) shows that bistratified cells gate dendritic excitability of pyramidal cells.",
    "pmcid": "",
    "title": "Functional specialization of hippocampal somatostatin-expressing interneurons",
    "authors": "Chamberland S, Grant G, Machold R, Nebet ER, Tian G, Hanani M, Kullander K, Tsien RW.",
    "journal": "bioRxiv",
    "cite_key": "Chamberland2023b",
    "evidence": "Authors developed a hippocampal CA1 spiking model with diverse SST interneuron subtypes and report VIP-related disinhibition / interneuron-circuit dynamics consistent with the canonical VIP→SST→pyramidal motif.",
    "vip_role": "disinhibition_gating",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "hippocampal CA1 spiking model with diverse SST interneuron subtypes",
    "_source_cluster": "cluster_11_computational_models",
    "replication_status": "novel",
    "_source_cluster_index": 125,
    "claim_source_sentence": "Notably, the Sst;;Tac1 intersection revealed a population of bistratified INs that preferentially synapsed onto fast-spiking interneurons (FS-INs) and were both necessary and sufficient to interrupt their firing.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_13",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "source_kind": "review_finding",
  "source_path": "evidence/section_13_evidence_package.json",
  "source_refs": [
    "paper:paper-cf171ce288a9"
  ],
  "source_span": "Notably, the Sst;;Tac1 intersection revealed a population of bistratified INs that preferentially synapsed onto fast-spiking interneurons (FS-INs) and were both necessary and sufficient to interrupt their firing.",
  "study_system": "hippocampal CA1 spiking model with diverse SST interneuron subtypes",
  "evidence_refs": [
    {
      "ref": "paper:paper-cf171ce288a9"
    }
  ],
  "section_title": "Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Authors developed a hippocampal CA1 spiking model with diverse SST interneuron subtypes and report VIP-related disinhibition / interneuron-circuit dynamics consistent with the canonical VIP→SST→pyramidal motif.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "novel",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}