Details
- scope
- hippocampal CA1 spiking model with diverse SST interneuron subtypes
- claim_text
- A hippocampal CA1 model with subtype-specific somatostatin interneurons (OLM, bistratified, BC) shows that bistratified cells gate dendritic excitability of pyramidal cells.
- section_id
- section_13
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-13-conclusion
- source_kind
- review_finding
- source_path
- evidence/section_13_evidence_package.json
- source_span
- Notably, the Sst;;Tac1 intersection revealed a population of bistratified INs that preferentially synapsed onto fast-spiking interneurons (FS-INs) and were both necessary and sufficient to interrupt their firing.
- study_system
- hippocampal CA1 spiking model with diverse SST interneuron subtypes
- section_title
- Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor
- evidence_summary
- Authors developed a hippocampal CA1 spiking model with diverse SST interneuron subtypes and report VIP-related disinhibition / interneuron-circuit dynamics consistent with the canonical VIP→SST→pyramidal motif.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- novel
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-13-conclusion
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (4)
- raw_fields
{ "n": null, "id": "cluster_11_finding_126", "doi": "10.1101/2023.04.27.538511", "pmid": "", "year": "2023", "claim": "A hippocampal CA1 model with subtype-specific somatostatin interneurons (OLM, bistratified, BC) shows that bistratified cells gate dendritic excitability of pyramidal cells.", "pmcid": "", "title": "Functional specialization of hippocampal somatostatin-expressing interneurons", "authors": "Chamberland S, Grant G, Machold R, Nebet ER, Tian G, Hanani M, Kullander K, Tsien RW.", "journal": "bioRxiv", "cite_key": "Chamberland2023b", "evidence": "Authors developed a hippocampal CA1 spiking model with diverse SST interneuron subtypes and report VIP-related disinhibition / interneuron-circuit dynamics consistent with the canonical VIP→SST→pyramidal motif.", "vip_role": "disinhibition_gating", "effect_size": null, "text_access": "abstract_only", "study_system": "hippocampal CA1 spiking model with diverse SST interneuron subtypes", "_source_cluster": "cluster_11_computational_models", "replication_status": "novel", "_source_cluster_index": 125, "claim_source_sentence": "Notably, the Sst;;Tac1 intersection revealed a population of bistratified INs that preferentially synapsed onto fast-spiking interneurons (FS-INs) and were both necessary and sufficient to interrupt their firing.", "replication_evidence_dois": [], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-cf171ce288a9" ]
- evidence_refs
[ { "ref": "paper:paper-cf171ce288a9" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }