Version history

{
  "scope": "human MTG vs mouse VISp/ALM; cross-species snRNA-seq",
  "claim_text": "Hodge et al. (2019) found that interneuron-discriminating gene sets were largely conserved between mouse and human, supporting alignment of homologous interneuron subtypes (~37 homologous t-types) despite species-specific expression differences.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41586-019-1506-7",
    "claim": "Hodge et al. (2019) found that interneuron-discriminating gene sets were largely conserved between mouse and human, supporting alignment of homologous interneuron subtypes (~37 homologous t-types) despite species-specific expression differences.",
    "title": null,
    "cite_key": "Hodge2019",
    "evidence": "MetaNeighbor cross-species mapping aligned ~37 homologous interneuron t-types between human MTG and mouse VISp/ALM; VIP and SST subclasses showed conserved markers but expanded type diversity in human.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "human MTG vs mouse VISp/ALM; cross-species snRNA-seq",
    "target_section": "section_02",
    "_source_cluster": "cluster_01_molecular_taxonomy",
    "replication_status": "replicated",
    "_source_cluster_index": 6,
    "claim_source_sentence": "Matching cell types requires shared expression patterns between species, and we find that gene families (mean = 21 genes/set) that best discriminate mouse interneurons also discriminate human interneurons."
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-pm-31435019"
  ],
  "source_span": "Matching cell types requires shared expression patterns between species, and we find that gene families (mean = 21 genes/set) that best discriminate mouse interneurons also discriminate human interneurons.",
  "study_system": "human MTG vs mouse VISp/ALM; cross-species snRNA-seq",
  "evidence_refs": [
    {
      "ref": "paper:paper-pm-31435019"
    }
  ],
  "section_title": "Species Differences, Human Relevance, and Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "MetaNeighbor cross-species mapping aligned ~37 homologous interneuron t-types between human MTG and mouse VISp/ALM; VIP and SST subclasses showed conserved markers but expanded type diversity in human.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-11-disease-translational",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_11_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}