Version history

{
  "scope": "mouse primary motor cortex, MERFISH single-cell spatial transcriptomics (~300,000 cells)",
  "claim_text": "A MERFISH-based spatial cell atlas of mouse primary motor cortex profiling ~300,000 cells identifies 95 neuronal and non-neuronal clusters; intratelencephalic (IT) neurons form a continuous gradient along cortical depth in which gene expression of individual cells correlates with their cortical depth, and inhibitory neuronal clusters also adopt laminar organizations.",
  "raw_fields": {
    "n": "~300,000 cells; 95 clusters",
    "doi": "10.1038/s41586-021-03705-x",
    "claim": "A MERFISH-based spatial cell atlas of mouse primary motor cortex profiling ~300,000 cells identifies 95 neuronal and non-neuronal clusters; intratelencephalic (IT) neurons form a continuous gradient along cortical depth in which gene expression of individual cells correlates with their cortical depth, and inhibitory neuronal clusters also adopt laminar organizations.",
    "cite_key": "Zhang2021c",
    "evidence": "MERFISH multiplexed in situ profiling of ~300,000 cells in mouse M1 combined with retrograde labeling to map projection targets.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse primary motor cortex, MERFISH single-cell spatial transcriptomics (~300,000 cells)",
    "argument_role": "supporting",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "We profiled approximately 300,000 cells in the mouse primary motor cortex and its adjacent areas, identified 95 neuronal and non-neuronal cell clusters, and revealed a complex spatial map in which not only excitatory but also most inhibitory neuronal clusters adopted laminar organizations. Intratelencephalic neurons formed a largely continuous gradient along the cortical depth axis, in which the gene expression of individual cells correlated with their cortical depths.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_02",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_02_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-bbfc9a9ee9e9"
  ],
  "source_span": "We profiled approximately 300,000 cells in the mouse primary motor cortex and its adjacent areas, identified 95 neuronal and non-neuronal cell clusters, and revealed a complex spatial map in which not only excitatory but also most inhibitory neuronal clusters adopted laminar organizations. Intratelencephalic neurons formed a largely continuous gradient along the cortical depth axis, in which the gene expression of i...",
  "study_system": "mouse primary motor cortex, MERFISH single-cell spatial transcriptomics (~300,000 cells)",
  "evidence_refs": [
    {
      "ref": "paper:paper-bbfc9a9ee9e9"
    }
  ],
  "section_title": "2. Mouse-cortex anatomy primer — areal map, layer structure, projection-class nomenclature (IT / PT / CT), tools available for E→E dissection (paired patch, Cre lines, two-photon-targeted patch, optogenetics, EM reconstruction)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "MERFISH multiplexed in situ profiling of ~300,000 cells in mouse M1 combined with retrograde labeling to map projection targets.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_02_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}