Version history

{
  "scope": "mouse, Nkx2.1 knockout, MGE slice culture",
  "claim_text": "NKX2.1 specifies cortical interneuron fate by directly activating Lhx6 transcription",
  "raw_fields": {
    "n": 0,
    "doi": "10.1242/dev.015123",
    "claim": "NKX2.1 specifies cortical interneuron fate by directly activating Lhx6 transcription",
    "evidence": "Electroporation of Nkx2.1 into Nkx2.1-/- MGE slice cultures rescued PV and SST interneuron production; Lhx6 was induced and shown necessary and sufficient for rescue",
    "effect_size": "rescue of PV- and SST-expressing cells in Nkx2.1-/- transplants",
    "text_access": "abstract_only",
    "study_system": "mouse, Nkx2.1 knockout, MGE slice culture",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "NKX2.1 protein binds a highly conserved sequence in the Lhx6 promoter, and this sequence appears to mediate the direct activation of Lhx6 by NKX2.1.",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2014.02.030",
      "10.1523/jneurosci.3496-17.2018"
    ],
    "effect_size_source_sentence": "gain- and loss-of-function studies suggest that Lhx6 is necessary and sufficient to rescue these and other interneuron phenotypes in cells transplanted from Nkx2.1-/- slices"
  },
  "section_id": "section_03_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json",
  "effect_size": "rescue of PV- and SST-expressing cells in Nkx2.1-/- transplants",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-03",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-a9cd8f097456"
  ],
  "source_span": "NKX2.1 protein binds a highly conserved sequence in the Lhx6 promoter, and this sequence appears to mediate the direct activation of Lhx6 by NKX2.1.",
  "study_system": "mouse, Nkx2.1 knockout, MGE slice culture",
  "evidence_refs": [
    {
      "ref": "paper:paper-a9cd8f097456"
    }
  ],
  "section_title": "Developmental Origins: MGE Lineage, Specification, and Migration",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Electroporation of Nkx2.1 into Nkx2.1-/- MGE slice cultures rescued PV and SST interneuron production; Lhx6 was induced and shown necessary and sufficient for rescue",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-03",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}