Version history

{
  "scope": "awake mouse primary somatosensory (barrel) cortex layer 2/3 in vivo",
  "claim_text": "In-vivo single-cell optogenetic activation of individual L2/3 pyramidal neurons combined with whole-cell recording of identified PV+ and SST+ GABAergic neurons in mouse barrel cortex shows that PV+ neurons receive large, fast, low-failure-rate unitary glutamatergic inputs from L2/3 pyramidal neurons whereas SST+ neurons receive smaller, slower, more variable inputs — establishing in-vivo unitary E→I synaptic transmission properties in awake mouse cortex.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuron.2014.11.025",
    "claim": "In-vivo single-cell optogenetic activation of individual L2/3 pyramidal neurons combined with whole-cell recording of identified PV+ and SST+ GABAergic neurons in mouse barrel cortex shows that PV+ neurons receive large, fast, low-failure-rate unitary glutamatergic inputs from L2/3 pyramidal neurons whereas SST+ neurons receive smaller, slower, more variable inputs — establishing in-vivo unitary E→I synaptic transmission properties in awake mouse cortex.",
    "cite_key": "Pala2015",
    "evidence": "Single-cell optogenetic activation of individual ChR2-expressing L2/3 pyramidal neurons in vivo combined with targeted whole-cell recordings from genetically identified PV+ and SST+ interneurons in mouse barrel cortex.",
    "effect_size": "qualitative — cell-type-specific in-vivo unitary EPSP amplitude and kinetics differ between PV and SST targets",
    "text_access": "fulltext",
    "study_system": "awake mouse primary somatosensory (barrel) cortex layer 2/3 in vivo",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "We found that parvalbumin-expressing (PV) GABAergic neurons received unitary glutamatergic synaptic input",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.7554/eLife.35869"
    ],
    "effect_size_source_sentence": "parvalbumin-expressing (PV) GABAergic neurons received unitary glutamatergic synaptic input"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "qualitative — cell-type-specific in-vivo unitary EPSP amplitude and kinetics differ between PV and SST targets",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-17b36d5093c6"
  ],
  "source_span": "We found that parvalbumin-expressing (PV) GABAergic neurons received unitary glutamatergic synaptic input",
  "study_system": "awake mouse primary somatosensory (barrel) cortex layer 2/3 in vivo",
  "evidence_refs": [
    {
      "ref": "paper:paper-17b36d5093c6"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Single-cell optogenetic activation of individual ChR2-expressing L2/3 pyramidal neurons in vivo combined with targeted whole-cell recordings from genetically identified PV+ and SST+ interneurons in mouse barrel cortex.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}