In-vivo single-cell optogenetic activation of individual L2/3 pyramidal neurons…

In-vivo single-cell optogenetic activation of individual L2/3 pyramidal neurons combined with whole-cell recording of identified PV+ and SST+ GABAergic neurons in mouse barrel cortex shows that PV+ neurons receive large, fast, low-failure-rate unitary glutamatergic inputs from L2/3 pyramidal neurons whereas SST+ neurons receive smaller, slower, more variable inputs — establishing in-vivo unitary E→I synaptic transmission properties in awake mouse cortex.

{
  "n": 0,
  "doi": "10.1016/j.neuron.2014.11.025",
  "claim": "In-vivo single-cell optogenetic activation of individual L2/3 pyramidal neurons combined with whole-cell recording of identified PV+ and SST+ GABAergic neurons in mouse barrel cortex shows that PV+ neurons receive large, fast, low-failure-rate unitary glutamatergic inputs from L2/3 pyramidal neurons whereas SST+ neurons receive smaller, slower, more variable inputs — establishing in-vivo unitary E→I synaptic transmission properties in awake mouse cortex.",
  "cite_key": "Pala2015",
  "evidence": "Single-cell optogenetic activation of individual ChR2-expressing L2/3 pyramidal neurons in vivo combined with targeted whole-cell recordings from genetically identified PV+ and SST+ interneurons in mouse barrel cortex.",
  "effect_size": "qualitative — cell-type-specific in-vivo unitary EPSP amplitude and kinetics differ between PV and SST targets",
  "text_access": "fulltext",
  "study_system": "awake mouse primary somatosensory (barrel) cortex layer 2/3 in vivo",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "We found that parvalbumin-expressing (PV) GABAergic neurons received unitary glutamatergic synaptic input",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.7554/eLife.35869"
  ],
  "effect_size_source_sentence": "parvalbumin-expressing (PV) GABAergic neurons received unitary glutamatergic synaptic input"
}

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