In a biophysical V1 layer 2/3 microcircuit model, PV and SST interneurons prefe…

In a biophysical V1 layer 2/3 microcircuit model, PV and SST interneurons preferentially induce gamma (30–80 Hz) and beta (20–30 Hz) firing of pyramidal neurons respectively, while rapid VIP→SST inhibition is required for attentional modulation of low-gamma (30–50 Hz) power.

{
  "n": null,
  "doi": "10.1093/cercor/bhac355",
  "pmid": "36130096",
  "year": "2023",
  "claim": "In a biophysical V1 layer 2/3 microcircuit model, PV and SST interneurons preferentially induce gamma (30–80 Hz) and beta (20–30 Hz) firing of pyramidal neurons respectively, while rapid VIP→SST inhibition is required for attentional modulation of low-gamma (30–50 Hz) power.",
  "pmcid": "PMC10110453",
  "title": "A microcircuit model involving parvalbumin, somatostatin, and vasoactive intestinal polypeptide inhibitory interneurons for the modulation of neuronal oscillation during visual processing.",
  "authors": "",
  "journal": "",
  "cite_key": "Wagatsuma2023",
  "evidence": "Computational simulations of a Pyr-PV-SST-VIP V1 microcircuit; sweep over VIP→SST synaptic weight and delay reproduces frequency-band-specific roles.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "VIP→SST synaptic weight WVIP-SOM=0.5 abolishes attentional gamma modulation; delay dVIP-SOM modulates low-gamma magnitude",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "biophysical computational model of mouse V1 layers 2/3",
  "cited_by_count": 35,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 3,
  "claim_source_sentence": "In simulations with our model, inhibitory signals from PV and SOM neurons preferentially induced neuronal firing at gamma (30-80 Hz) and beta (20-30 Hz) frequencies, respectively, in agreement with observed physiological results. Furthermore, our model indicated that rapid inhibition from VIP to SOM subtypes underlies marked attentional modulation for low-gamma frequency (30-50 Hz) in Pyr neuron responses.",
  "replication_evidence_dois": [
    "10.1016/j.neuron.2022.10.036",
    "10.7554/elife.77594"
  ],
  "effect_size_source_sentence": "the attentional effects of STH power for the gamma-band activity of Pyr neurons was not observed in the model simulation with WVIP-SOM of 0.5"
}

[
  "paper:paper-e8c0e080f1f9"
]

In simulations with our model, inhibitory signals from PV and SOM neurons preferentially induced neuronal firing at gamma (30-80 Hz) and beta (20-30 Hz) frequencies, respectively, in agreement with observed physiological results. Furthermore, our model indicated that rapid inhibition from VIP to SOM subtypes underlies marked attentional modulation for low-gamma frequency (30-50 Hz) in Pyr neuron responses.

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    "ref": "paper:paper-e8c0e080f1f9"
  }
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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