Version history

{
  "scope": "biophysical computational model of mouse V1 layers 2/3",
  "claim_text": "In a biophysical V1 layer 2/3 microcircuit model, PV and SST interneurons preferentially induce gamma (30–80 Hz) and beta (20–30 Hz) firing of pyramidal neurons respectively, while rapid VIP→SST inhibition is required for attentional modulation of low-gamma (30–50 Hz) power.",
  "raw_fields": {
    "n": null,
    "doi": "10.1093/cercor/bhac355",
    "pmid": "36130096",
    "year": "2023",
    "claim": "In a biophysical V1 layer 2/3 microcircuit model, PV and SST interneurons preferentially induce gamma (30–80 Hz) and beta (20–30 Hz) firing of pyramidal neurons respectively, while rapid VIP→SST inhibition is required for attentional modulation of low-gamma (30–50 Hz) power.",
    "pmcid": "PMC10110453",
    "title": "A microcircuit model involving parvalbumin, somatostatin, and vasoactive intestinal polypeptide inhibitory interneurons for the modulation of neuronal oscillation during visual processing.",
    "authors": "",
    "journal": "",
    "cite_key": "Wagatsuma2023",
    "evidence": "Computational simulations of a Pyr-PV-SST-VIP V1 microcircuit; sweep over VIP→SST synaptic weight and delay reproduces frequency-band-specific roles.",
    "cluster_id": "cluster_09_oscillations",
    "effect_size": "VIP→SST synaptic weight WVIP-SOM=0.5 abolishes attentional gamma modulation; delay dVIP-SOM modulates low-gamma magnitude",
    "figure_data": [],
    "text_access": "fulltext",
    "study_system": "biophysical computational model of mouse V1 layers 2/3",
    "cited_by_count": 35,
    "_source_cluster": "cluster_09_oscillations",
    "replication_status": "independently_replicated",
    "_source_cluster_index": 3,
    "claim_source_sentence": "In simulations with our model, inhibitory signals from PV and SOM neurons preferentially induced neuronal firing at gamma (30-80 Hz) and beta (20-30 Hz) frequencies, respectively, in agreement with observed physiological results. Furthermore, our model indicated that rapid inhibition from VIP to SOM subtypes underlies marked attentional modulation for low-gamma frequency (30-50 Hz) in Pyr neuron responses.",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2022.10.036",
      "10.7554/elife.77594"
    ],
    "effect_size_source_sentence": "the attentional effects of STH power for the gamma-band activity of Pyr neurons was not observed in the model simulation with WVIP-SOM of 0.5"
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "VIP→SST synaptic weight WVIP-SOM=0.5 abolishes attentional gamma modulation; delay dVIP-SOM modulates low-gamma magnitude",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-e8c0e080f1f9"
  ],
  "source_span": "In simulations with our model, inhibitory signals from PV and SOM neurons preferentially induced neuronal firing at gamma (30-80 Hz) and beta (20-30 Hz) frequencies, respectively, in agreement with observed physiological results. Furthermore, our model indicated that rapid inhibition from VIP to SOM subtypes underlies marked attentional modulation for low-gamma frequency (30-50 Hz) in Pyr neuron responses.",
  "study_system": "biophysical computational model of mouse V1 layers 2/3",
  "evidence_refs": [
    {
      "ref": "paper:paper-e8c0e080f1f9"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Computational simulations of a Pyr-PV-SST-VIP V1 microcircuit; sweep over VIP→SST synaptic weight and delay reproduces frequency-band-specific roles.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}