Version history

{
  "scope": "mouse S1 C2 barrel column, paired whole-cell recordings between excitatory neurons across layers",
  "claim_text": "Paired whole-cell recordings between excitatory neurons across layers of mouse C2 barrel column show layer-dependent short-term synaptic plasticity: depression dominates at most E→E connections, but presynaptic layer-2 neurons give rise to facilitating outputs at 10–30 ms interspike intervals, indicating that supragranular pyramidal bursts are preferentially amplified by their own intracortical synapses.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1093/cercor/bhx094",
    "claim": "Paired whole-cell recordings between excitatory neurons across layers of mouse C2 barrel column show layer-dependent short-term synaptic plasticity: depression dominates at most E→E connections, but presynaptic layer-2 neurons give rise to facilitating outputs at 10–30 ms interspike intervals, indicating that supragranular pyramidal bursts are preferentially amplified by their own intracortical synapses.",
    "cite_key": "Lefort2017",
    "evidence": "In vitro paired whole-cell recordings between excitatory neurons in different layers of the C2 barrel column in mouse S1 slices; testing of paired-pulse responses across multiple intervals (10–300 ms) per layer combination.",
    "effect_size": "L2 presynaptic E→E synapses show facilitation at 10–30 ms ISI; depression dominant in other layer pairs",
    "text_access": "abstract_only",
    "study_system": "mouse S1 C2 barrel column, paired whole-cell recordings between excitatory neurons across layers",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "We find layer-dependent short-term plasticity, with depression being dominant at many synaptic connections.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2008.12.020"
    ],
    "effect_size_source_sentence": "Interestingly, however, presynaptic layer 2 neurons predominantly give rise to facilitating excitatory synaptic output at short interspike intervals of 10 and 30 ms."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "L2 presynaptic E→E synapses show facilitation at 10–30 ms ISI; depression dominant in other layer pairs",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-1f2e0ebd9f4c"
  ],
  "source_span": "We find layer-dependent short-term plasticity, with depression being dominant at many synaptic connections.",
  "study_system": "mouse S1 C2 barrel column, paired whole-cell recordings between excitatory neurons across layers",
  "evidence_refs": [
    {
      "ref": "paper:paper-1f2e0ebd9f4c"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "In vitro paired whole-cell recordings between excitatory neurons in different layers of the C2 barrel column in mouse S1 slices; testing of paired-pulse responses across multiple intervals (10–300 ms) per layer combination.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}