Paired whole-cell recordings between excitatory neurons across layers of mouse…

Paired whole-cell recordings between excitatory neurons across layers of mouse C2 barrel column show layer-dependent short-term synaptic plasticity: depression dominates at most E→E connections, but presynaptic layer-2 neurons give rise to facilitating outputs at 10–30 ms interspike intervals, indicating that supragranular pyramidal bursts are preferentially amplified by their own intracortical synapses.

{
  "n": 0,
  "doi": "10.1093/cercor/bhx094",
  "claim": "Paired whole-cell recordings between excitatory neurons across layers of mouse C2 barrel column show layer-dependent short-term synaptic plasticity: depression dominates at most E→E connections, but presynaptic layer-2 neurons give rise to facilitating outputs at 10–30 ms interspike intervals, indicating that supragranular pyramidal bursts are preferentially amplified by their own intracortical synapses.",
  "cite_key": "Lefort2017",
  "evidence": "In vitro paired whole-cell recordings between excitatory neurons in different layers of the C2 barrel column in mouse S1 slices; testing of paired-pulse responses across multiple intervals (10–300 ms) per layer combination.",
  "effect_size": "L2 presynaptic E→E synapses show facilitation at 10–30 ms ISI; depression dominant in other layer pairs",
  "text_access": "abstract_only",
  "study_system": "mouse S1 C2 barrel column, paired whole-cell recordings between excitatory neurons across layers",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "We find layer-dependent short-term plasticity, with depression being dominant at many synaptic connections.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1016/j.neuron.2008.12.020"
  ],
  "effect_size_source_sentence": "Interestingly, however, presynaptic layer 2 neurons predominantly give rise to facilitating excitatory synaptic output at short interspike intervals of 10 and 30 ms."
}

[
  "paper:paper-1f2e0ebd9f4c"
]

[
  {
    "ref": "paper:paper-1f2e0ebd9f4c"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}