VIP+ and L1 interneurons in mouse V1 are facilitated by ACh at lower agonist do…

VIP+ and L1 interneurons in mouse V1 are facilitated by ACh at lower agonist doses (depolarization at 100 µM) than SOM neurons (which fire only at 10 mM), and at intermediate ACh (1–100 µM) VIP/L1 receive an inhibitory IPSC barrage while SOM cells do not — defining a dose-dependent inhibitory hierarchy that gates VIP firing recruitment in vivo.

{
  "n": null,
  "doi": "10.1038/nn.4002",
  "claim": "VIP+ and L1 interneurons in mouse V1 are facilitated by ACh at lower agonist doses (depolarization at 100 µM) than SOM neurons (which fire only at 10 mM), and at intermediate ACh (1–100 µM) VIP/L1 receive an inhibitory IPSC barrage while SOM cells do not — defining a dose-dependent inhibitory hierarchy that gates VIP firing recruitment in vivo.",
  "title": null,
  "cite_key": "Chen2015a",
  "evidence": "ex vivo whole-cell current clamp of SOM-tdTom, VIP-tdTom, L1 inhibitory neurons; ACh dose-response with NBQX",
  "effect_size": "VIP/L1 fire at 10 mM ACh; depolarize at 100 μM. SOM fires already at 10 μM",
  "text_access": "fulltext",
  "study_system": "mouse V1, VIP/SOM-tdTom × WT slices",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 38,
  "claim_source_sentence": "These responses were also concentration specific: ACh at 1-100 μM induced responses in VIP and L1 neurons but minimally in SOM neurons while ACh at 10 mM induced large responses in all 3 cell types (Fig.",
  "replication_evidence_dois": [
    "10.7554/elife.46846",
    "10.1093/cercor/bhv202"
  ],
  "effect_size_source_sentence": "VIP and L1 neurons depolarized at 100 μM ACh but fired only at 10 mM ACh."
}

[
  "paper:paper-2c3589e2f07a"
]

[
  {
    "ref": "paper:paper-2c3589e2f07a"
  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}