Details
- scope
- 5xFAD mouse model, hippocampal CA1 slices
- claim_text
- PV basket cell activity is selectively reduced during hippocampal sharp-wave ripples in 5xFAD mice, while bistratified and axo-axonic cells are unimpaired
- section_id
- section_09_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json
- effect_size
- 46% spike rate reduction in PVBCs during SWRs; 50% reduction in excitatory drive; 33% increase in SWR frequency; 58% increase in SWR amplitude
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-09
- source_kind
- review_finding
- source_path
- evidence/section_09_evidence_package.json
- source_span
- We observed a 46% spike rate reduction during SWRs in PV basket cells (PVBCs), while PV bistratified and axo-axonic cells were unimpaired. Excitatory synaptic drive to PVBCs was selectively reduced by 50%, resulting in decreased E/I ratio.
- study_system
- 5xFAD mouse model, hippocampal CA1 slices
- section_title
- Brain Region and Layer Context: Beyond Primary Sensory Cortex
- evidence_summary
- PV basket cell activity is selectively reduced during hippocampal sharp-wave ripples in 5xFAD mice, while bistratified and axo-axonic cells are unimpaired
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-09
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1523/JNEUROSCI.0425-20.2020", "claim": "PV basket cell activity is selectively reduced during hippocampal sharp-wave ripples in 5xFAD mice, while bistratified and axo-axonic cells are unimpaired", "evidence": "PV basket cell activity is selectively reduced during hippocampal sharp-wave ripples in 5xFAD mice, while bistratified and axo-axonic cells are unimpaired", "effect_size": "46% spike rate reduction in PVBCs during SWRs; 50% reduction in excitatory drive; 33% increase in SWR frequency; 58% increase in SWR amplitude", "text_access": "fulltext", "study_system": "5xFAD mouse model, hippocampal CA1 slices", "replication_status": "replication_unknown", "claim_source_sentence": "We observed a 46% spike rate reduction during SWRs in PV basket cells (PVBCs), while PV bistratified and axo-axonic cells were unimpaired. Excitatory synaptic drive to PVBCs was selectively reduced by 50%, resulting in decreased E/I ratio.", "replication_evidence_dois": [], "effect_size_source_sentence": "We observed a 46% spike rate reduction during SWRs in PV basket cells (PVBCs). Excitatory synaptic drive to PVBCs was selectively reduced by 50%. We observed a 33% increase in frequency, 58% increase in amplitude, and 8% decrease in duration of SWRs." }- source_refs
[ "paper:paper-54726517a4fb" ]
- evidence_refs
[ { "ref": "paper:paper-54726517a4fb" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }