Version history

{
  "scope": "5xFAD mouse model, hippocampal CA1 slices",
  "claim_text": "PV basket cell activity is selectively reduced during hippocampal sharp-wave ripples in 5xFAD mice, while bistratified and axo-axonic cells are unimpaired",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/JNEUROSCI.0425-20.2020",
    "claim": "PV basket cell activity is selectively reduced during hippocampal sharp-wave ripples in 5xFAD mice, while bistratified and axo-axonic cells are unimpaired",
    "evidence": "PV basket cell activity is selectively reduced during hippocampal sharp-wave ripples in 5xFAD mice, while bistratified and axo-axonic cells are unimpaired",
    "effect_size": "46% spike rate reduction in PVBCs during SWRs; 50% reduction in excitatory drive; 33% increase in SWR frequency; 58% increase in SWR amplitude",
    "text_access": "fulltext",
    "study_system": "5xFAD mouse model, hippocampal CA1 slices",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "We observed a 46% spike rate reduction during SWRs in PV basket cells (PVBCs), while PV bistratified and axo-axonic cells were unimpaired. Excitatory synaptic drive to PVBCs was selectively reduced by 50%, resulting in decreased E/I ratio.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "We observed a 46% spike rate reduction during SWRs in PV basket cells (PVBCs). Excitatory synaptic drive to PVBCs was selectively reduced by 50%. We observed a 33% increase in frequency, 58% increase in amplitude, and 8% decrease in duration of SWRs."
  },
  "section_id": "section_09_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json",
  "effect_size": "46% spike rate reduction in PVBCs during SWRs; 50% reduction in excitatory drive; 33% increase in SWR frequency; 58% increase in SWR amplitude",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-09",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-54726517a4fb"
  ],
  "source_span": "We observed a 46% spike rate reduction during SWRs in PV basket cells (PVBCs), while PV bistratified and axo-axonic cells were unimpaired. Excitatory synaptic drive to PVBCs was selectively reduced by 50%, resulting in decreased E/I ratio.",
  "study_system": "5xFAD mouse model, hippocampal CA1 slices",
  "evidence_refs": [
    {
      "ref": "paper:paper-54726517a4fb"
    }
  ],
  "section_title": "Brain Region and Layer Context: Beyond Primary Sensory Cortex",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "PV basket cell activity is selectively reduced during hippocampal sharp-wave ripples in 5xFAD mice, while bistratified and axo-axonic cells are unimpaired",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-09",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}