Version history

{
  "scope": "vip-interneurons",
  "claim_text": "In mouse prelimbic PFC, D1 dopamine receptors are enriched in superficial-layer VIP interneurons that co-express calretinin, and D1 agonists strongly enhance firing of these VIP+ cells while sparing PV and SOM cells, implicating VIP cells as cellular substrates of dopaminergic disinhibition in PFC.",
  "raw_fields": {
    "n": null,
    "doi": "10.1093/cercor/bhy299",
    "year": "2019",
    "claim": "In mouse prelimbic PFC, D1 dopamine receptors are enriched in superficial-layer VIP interneurons that co-express calretinin, and D1 agonists strongly enhance firing of these VIP+ cells while sparing PV and SOM cells, implicating VIP cells as cellular substrates of dopaminergic disinhibition in PFC.",
    "title": "Cell-Type-Specific D1 Dopamine Receptor Modulation of Projection Neurons and Interneurons in the Prefrontal Cortex",
    "journal": "",
    "species": "mouse",
    "cite_key": "Anastasiades2019",
    "evidence": "D1-Cre/Drd1a-tdTomato + slice electrophysiology and immunohistochemistry in mouse prelimbic PFC.",
    "effect_size": "D1 agonist enhanced action-potential firing in D1+ VIP cells; absent in PV/SOM cells.",
    "text_access": "fulltext",
    "_source_cluster": "cluster_13_neuromodulation",
    "replication_status": "single_study",
    "_source_cluster_index": 27,
    "claim_source_sentence": "D1 receptors are also present in interneurons and enriched in superficial layer VIP-positive (VIP+) interneurons that coexpresses calretinin but absent from parvalbumin-positive (PV+) and somatostatin-positive (SOM+) interneurons.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "D1 receptors strongly and selectively enhance action potential firing in only a subset of these corticocortical neurons and VIP+ interneurons."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json",
  "effect_size": "D1 agonist enhanced action-potential firing in D1+ VIP cells; absent in PV/SOM cells.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-08-in-vivo-behavior",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-54d3b0c8acb7"
  ],
  "source_span": "D1 receptors are also present in interneurons and enriched in superficial layer VIP-positive (VIP+) interneurons that coexpresses calretinin but absent from parvalbumin-positive (PV+) and somatostatin-positive (SOM+) interneurons.",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-54d3b0c8acb7"
    }
  ],
  "section_title": "In Vivo Function During Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "D1-Cre/Drd1a-tdTomato + slice electrophysiology and immunohistochemistry in mouse prelimbic PFC.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-08-in-vivo-behavior",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}