In mouse prelimbic PFC, D1 dopamine receptors are enriched in superficial-layer…

In mouse prelimbic PFC, D1 dopamine receptors are enriched in superficial-layer VIP interneurons that co-express calretinin, and D1 agonists strongly enhance firing of these VIP+ cells while sparing PV and SOM cells, implicating VIP cells as cellular substrates of dopaminergic disinhibition in PFC.

{
  "n": null,
  "doi": "10.1093/cercor/bhy299",
  "year": "2019",
  "claim": "In mouse prelimbic PFC, D1 dopamine receptors are enriched in superficial-layer VIP interneurons that co-express calretinin, and D1 agonists strongly enhance firing of these VIP+ cells while sparing PV and SOM cells, implicating VIP cells as cellular substrates of dopaminergic disinhibition in PFC.",
  "title": "Cell-Type-Specific D1 Dopamine Receptor Modulation of Projection Neurons and Interneurons in the Prefrontal Cortex",
  "journal": "",
  "species": "mouse",
  "cite_key": "Anastasiades2019",
  "evidence": "D1-Cre/Drd1a-tdTomato + slice electrophysiology and immunohistochemistry in mouse prelimbic PFC.",
  "effect_size": "D1 agonist enhanced action-potential firing in D1+ VIP cells; absent in PV/SOM cells.",
  "text_access": "fulltext",
  "_source_cluster": "cluster_13_neuromodulation",
  "replication_status": "single_study",
  "_source_cluster_index": 27,
  "claim_source_sentence": "D1 receptors are also present in interneurons and enriched in superficial layer VIP-positive (VIP+) interneurons that coexpresses calretinin but absent from parvalbumin-positive (PV+) and somatostatin-positive (SOM+) interneurons.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "D1 receptors strongly and selectively enhance action potential firing in only a subset of these corticocortical neurons and VIP+ interneurons."
}

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]

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  }
]

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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}