Details
- scope
- adult human neocortex (8 areas)
- section_id
- section_03
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
- effect_size
- 24 cell subclasses identified
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-03-development
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- Primary visual cortex showed characteristic organization with major changes in the excitatory to inhibitory neuron ratio, expansion of layer 4 excitatory neurons, and specialized inhibitory neurons.
- study_system
- adult human neocortex (8 areas)
- section_title
- Developmental Origins and Postnatal Maturation
- evidence_summary
- snRNA-seq across 8 areas, comparing cell-class proportions and laminar organization.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-03-development
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
Single-nucleus transcriptomics across 8 human cortical areas shows highly consistent presence of 24 cell subclasses but areal differences in inhibitory-neuron specialization, particularly in primary visual cortex which contains specialized inhibitory interneurons.
- raw_fields
{ "n": 0, "doi": "10.1126/science.adf6812", "claim": "Single-nucleus transcriptomics across 8 human cortical areas shows highly consistent presence of 24 cell subclasses but areal differences in inhibitory-neuron specialization, particularly in primary visual cortex which contains specialized inhibitory interneurons.", "title": null, "cite_key": "Jorstad2023b", "evidence": "snRNA-seq across 8 areas, comparing cell-class proportions and laminar organization.", "effect_size": "24 cell subclasses identified", "text_access": "abstract_only", "study_system": "adult human neocortex (8 areas)", "_source_cluster": "cluster_02_development_lineage", "replication_status": "replication_unknown", "_source_cluster_index": 50, "claim_source_sentence": "Primary visual cortex showed characteristic organization with major changes in the excitatory to inhibitory neuron ratio, expansion of layer 4 excitatory neurons, and specialized inhibitory neurons.", "replication_evidence_dois": [], "effect_size_source_sentence": "Single-nucleus RNA-sequencing of 8 areas spanning cortical structural variation showed a highly consistent cellular makeup for 24 cell subclasses." }- source_refs
[ "paper:paper-5be80ada1e38" ]
- evidence_refs
[ { "ref": "paper:paper-5be80ada1e38" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }