Version history

{
  "scope": "mouse cortico-striatal D1-Cre / D2-Cre",
  "claim_text": "Cre-targeted G-deleted rabies tracing reveals asymmetric overlap between cortical inputs to D1- and D2-SPNs: more than two-thirds of excitatory inputs to D2-SPNs also target D1-SPNs while only about one-third do so in the reverse direction, and pathway-specific corticostriatal projection optogenetic activation produces dissociable effects on locomotion, reinforcement learning and sequence behavior.",
  "raw_fields": {
    "n": 7,
    "doi": "10.7554/elife.92992",
    "claim": "Cre-targeted G-deleted rabies tracing reveals asymmetric overlap between cortical inputs to D1- and D2-SPNs: more than two-thirds of excitatory inputs to D2-SPNs also target D1-SPNs while only about one-third do so in the reverse direction, and pathway-specific corticostriatal projection optogenetic activation produces dissociable effects on locomotion, reinforcement learning and sequence behavior.",
    "cite_key": "Klug2025",
    "evidence": "",
    "effect_size": ">2/3 of D2-SPN inputs are also D1-SPN inputs vs 1/3 reverse",
    "text_access": "fulltext",
    "study_system": "mouse cortico-striatal D1-Cre / D2-Cre",
    "source_cluster_id": "cluster_10",
    "replication_status": "contested",
    "claim_source_sentence": "Here using a G-deleted rabies system in mice, we found that more than two-thirds of excitatory inputs to D2-SPNs also target D1-SPNs, while only one-third do so vice versa.",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2013.05.014"
    ],
    "effect_size_source_sentence": "Here using a G-deleted rabies system in mice, we found that more than two-thirds of excitatory inputs to D2-SPNs also target D1-SPNs, while only one-third do so vice versa."
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "effect_size": ">2/3 of D2-SPN inputs are also D1-SPN inputs vs 1/3 reverse",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-11",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-047f747899b8"
  ],
  "source_span": "Here using a G-deleted rabies system in mice, we found that more than two-thirds of excitatory inputs to D2-SPNs also target D1-SPNs, while only one-third do so vice versa.",
  "study_system": "mouse cortico-striatal D1-Cre / D2-Cre",
  "evidence_refs": [
    {
      "ref": "paper:paper-047f747899b8"
    }
  ],
  "section_title": "Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "contested",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-11",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}