Version history

{
  "scope": "Mouse V1, awake behaving; two-photon holographic optogenetics + visual task",
  "claim_text": "In mouse V1, activating just two 'pattern completion' neurons via two-photon holographic optogenetics is sufficient to recall a behaviorally relevant ensemble and alter behavioral performance — demonstrating that recurrent E→E connectivity supports causal ensemble recall at the smallest possible perturbation scale.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.cell.2019.05.045",
    "claim": "In mouse V1, activating just two 'pattern completion' neurons via two-photon holographic optogenetics is sufficient to recall a behaviorally relevant ensemble and alter behavioral performance — demonstrating that recurrent E→E connectivity supports causal ensemble recall at the smallest possible perturbation scale.",
    "cite_key": "CarrilloReid2019",
    "evidence": "Two-photon holographic stimulation + behavioral testing in awake mice performing a visual discrimination task; perturbation of pattern-completion vs non-selective neurons.",
    "effect_size": "activation of only two pattern-completion neurons reliably recalls full ensemble and improves behavioral performance; inappropriate behavior evoked by mistaken activation",
    "text_access": "abstract_only",
    "study_system": "Mouse V1, awake behaving; two-photon holographic optogenetics + visual task",
    "argument_role": "supporting",
    "replication_status": "within_lab",
    "claim_source_sentence": "Using two-photon holographic optogenetics in mouse primary visual cortex, we tested whether recalling ensembles by activating pattern completion neurons alters behavioral performance in a visual task.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1126/science.aaf7560"
    ],
    "effect_size_source_sentence": "Disruption of behaviorally relevant ensembles by activation of non-selective neurons decreased performance, whereas activation of only two pattern completion neurons from behaviorally relevant ensembles improved performance, by reliably recalling the whole ensemble."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "activation of only two pattern-completion neurons reliably recalls full ensemble and improves behavioral performance; inappropriate behavior evoked by mistaken activation",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-e37e0b6bad65"
  ],
  "source_span": "Using two-photon holographic optogenetics in mouse primary visual cortex, we tested whether recalling ensembles by activating pattern completion neurons alters behavioral performance in a visual task.",
  "study_system": "Mouse V1, awake behaving; two-photon holographic optogenetics + visual task",
  "evidence_refs": [
    {
      "ref": "paper:paper-e37e0b6bad65"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Two-photon holographic stimulation + behavioral testing in awake mice performing a visual discrimination task; perturbation of pattern-completion vs non-selective neurons.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "within_lab",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}