In mouse V1, activating just two 'pattern completion' neurons via two-photon ho…

In mouse V1, activating just two 'pattern completion' neurons via two-photon holographic optogenetics is sufficient to recall a behaviorally relevant ensemble and alter behavioral performance — demonstrating that recurrent E→E connectivity supports causal ensemble recall at the smallest possible perturbation scale.

{
  "n": 0,
  "doi": "10.1016/j.cell.2019.05.045",
  "claim": "In mouse V1, activating just two 'pattern completion' neurons via two-photon holographic optogenetics is sufficient to recall a behaviorally relevant ensemble and alter behavioral performance — demonstrating that recurrent E→E connectivity supports causal ensemble recall at the smallest possible perturbation scale.",
  "cite_key": "CarrilloReid2019",
  "evidence": "Two-photon holographic stimulation + behavioral testing in awake mice performing a visual discrimination task; perturbation of pattern-completion vs non-selective neurons.",
  "effect_size": "activation of only two pattern-completion neurons reliably recalls full ensemble and improves behavioral performance; inappropriate behavior evoked by mistaken activation",
  "text_access": "abstract_only",
  "study_system": "Mouse V1, awake behaving; two-photon holographic optogenetics + visual task",
  "argument_role": "supporting",
  "replication_status": "within_lab",
  "claim_source_sentence": "Using two-photon holographic optogenetics in mouse primary visual cortex, we tested whether recalling ensembles by activating pattern completion neurons alters behavioral performance in a visual task.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1126/science.aaf7560"
  ],
  "effect_size_source_sentence": "Disruption of behaviorally relevant ensembles by activation of non-selective neurons decreased performance, whereas activation of only two pattern completion neurons from behaviorally relevant ensembles improved performance, by reliably recalling the whole ensemble."
}

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