Version history

{
  "scope": "mouse hippocampal CA1 slices, optogenetic mapping",
  "claim_text": "In mouse hippocampal CA1, VIP/calretinin-positive type-III IS interneurons provide the major local inhibition to OLM cells with depressing, plasticity-resistant synapses; in contrast, septohippocampal GABAergic terminals produce strong, theta-LTP-capable inhibition—revealing two functionally distinct inhibitory pathways shaping OLM-driven theta inhibition.",
  "raw_fields": {
    "n": null,
    "doi": "10.3389/fncel.2010.00130",
    "pmid": "",
    "year": 2010,
    "claim": "In mouse hippocampal CA1, VIP/calretinin-positive type-III IS interneurons provide the major local inhibition to OLM cells with depressing, plasticity-resistant synapses; in contrast, septohippocampal GABAergic terminals produce strong, theta-LTP-capable inhibition—revealing two functionally distinct inhibitory pathways shaping OLM-driven theta inhibition.",
    "pmcid": "",
    "title": "Synapse-specific inhibitory control of hippocampal feedback inhibitory circuit",
    "authors": "",
    "journal": "",
    "cite_key": "Chamberland2010",
    "evidence": "Two-photon laser scanning photostimulation + whole-cell patch-clamp in mouse hippocampal slices; minimal stimulation IPSC analysis.",
    "cluster_id": "cluster_09_oscillations",
    "effect_size": "VIP-IS3 → OLM IPSCs small, paired-pulse depression; septohippocampal → OLM larger, theta-LTP-capable",
    "figure_data": [],
    "text_access": "fulltext",
    "study_system": "mouse hippocampal CA1 slices, optogenetic mapping",
    "cited_by_count": 78,
    "_source_cluster": "cluster_09_oscillations",
    "replication_status": "independently_replicated",
    "_source_cluster_index": 28,
    "claim_source_sentence": "Optical mapping of local inhibitory inputs to O-LM interneurons revealed that vasoactive intestinal polypeptide- and calretinin-positive neurons, with anatomical properties typical of type III interneuron-specific interneurons, provided the major local source of inhibition to O-LM cells. In contrast, synapses formed by septohippocampal projection produced higher amplitude and persistent inhibition and exhibited long-term potentiation induced by theta-like activity.",
    "replication_evidence_dois": [
      "10.1523/jneurosci.3813-13.2014"
    ],
    "effect_size_source_sentence": "Inhibitory postsynaptic currents evoked by minimal stimulation of this input exhibited small amplitude and significant paired-pulse and multiple-pulse depression during repetitive activity."
  },
  "section_id": "section_10",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "effect_size": "VIP-IS3 → OLM IPSCs small, paired-pulse depression; septohippocampal → OLM larger, theta-LTP-capable",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "source_kind": "review_finding",
  "source_path": "evidence/section_10_evidence_package.json",
  "source_refs": [
    "paper:paper-c0255e233af6"
  ],
  "source_span": "Optical mapping of local inhibitory inputs to O-LM interneurons revealed that vasoactive intestinal polypeptide- and calretinin-positive neurons, with anatomical properties typical of type III interneuron-specific interneurons, provided the major local source of inhibition to O-LM cells. In contrast, synapses formed by septohippocampal projection produced higher amplitude and persistent inhibition and exhibited long...",
  "study_system": "mouse hippocampal CA1 slices, optogenetic mapping",
  "evidence_refs": [
    {
      "ref": "paper:paper-c0255e233af6"
    }
  ],
  "section_title": "Oscillatory Dynamics and Temporal Coordination",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Two-photon laser scanning photostimulation + whole-cell patch-clamp in mouse hippocampal slices; minimal stimulation IPSC analysis.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}