In mouse hippocampal CA1, VIP/calretinin-positive type-III IS interneurons prov…

In mouse hippocampal CA1, VIP/calretinin-positive type-III IS interneurons provide the major local inhibition to OLM cells with depressing, plasticity-resistant synapses; in contrast, septohippocampal GABAergic terminals produce strong, theta-LTP-capable inhibition—revealing two functionally distinct inhibitory pathways shaping OLM-driven theta inhibition.

{
  "n": null,
  "doi": "10.3389/fncel.2010.00130",
  "pmid": "",
  "year": 2010,
  "claim": "In mouse hippocampal CA1, VIP/calretinin-positive type-III IS interneurons provide the major local inhibition to OLM cells with depressing, plasticity-resistant synapses; in contrast, septohippocampal GABAergic terminals produce strong, theta-LTP-capable inhibition—revealing two functionally distinct inhibitory pathways shaping OLM-driven theta inhibition.",
  "pmcid": "",
  "title": "Synapse-specific inhibitory control of hippocampal feedback inhibitory circuit",
  "authors": "",
  "journal": "",
  "cite_key": "Chamberland2010",
  "evidence": "Two-photon laser scanning photostimulation + whole-cell patch-clamp in mouse hippocampal slices; minimal stimulation IPSC analysis.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "VIP-IS3 → OLM IPSCs small, paired-pulse depression; septohippocampal → OLM larger, theta-LTP-capable",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "mouse hippocampal CA1 slices, optogenetic mapping",
  "cited_by_count": 78,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 28,
  "claim_source_sentence": "Optical mapping of local inhibitory inputs to O-LM interneurons revealed that vasoactive intestinal polypeptide- and calretinin-positive neurons, with anatomical properties typical of type III interneuron-specific interneurons, provided the major local source of inhibition to O-LM cells. In contrast, synapses formed by septohippocampal projection produced higher amplitude and persistent inhibition and exhibited long-term potentiation induced by theta-like activity.",
  "replication_evidence_dois": [
    "10.1523/jneurosci.3813-13.2014"
  ],
  "effect_size_source_sentence": "Inhibitory postsynaptic currents evoked by minimal stimulation of this input exhibited small amplitude and significant paired-pulse and multiple-pulse depression during repetitive activity."
}

[
  "paper:paper-c0255e233af6"
]

Optical mapping of local inhibitory inputs to O-LM interneurons revealed that vasoactive intestinal polypeptide- and calretinin-positive neurons, with anatomical properties typical of type III interneuron-specific interneurons, provided the major local source of inhibition to O-LM cells. In contrast, synapses formed by septohippocampal projection produced higher amplitude and persistent inhibition and exhibited long...

[
  {
    "ref": "paper:paper-c0255e233af6"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}