- claim_text
Functionally specific subnetworks in mouse V1 L2/3 emerge only after eye opening: at eye opening connectivity is unrelated to feature selectivity, then connections rearrange so similarly-tuned neurons become preferentially connected while connections among unresponsive cells are pruned.
- raw_fields
{
"n": 0,
"doi": "10.1038/nature12015",
"claim": "Functionally specific subnetworks in mouse V1 L2/3 emerge only after eye opening: at eye opening connectivity is unrelated to feature selectivity, then connections rearrange so similarly-tuned neurons become preferentially connected while connections among unresponsive cells are pruned.",
"cite_key": "Ko2013",
"evidence": "Two-photon calcium imaging in vivo followed by multiple whole-cell recordings in vitro of L2/3 pyramidal neurons in mouse V1 across postnatal ages.",
"effect_size": "Selective subnetwork formation post eye opening with overall connectivity rate unchanged.",
"text_access": "abstract_only",
"study_system": "mouse V1 L2/3 across postnatal ages; 2P + paired patch",
"argument_role": "supporting",
"replication_status": "independently_replicated",
"claim_source_sentence": "Although neural responses were already highly selective for visual stimuli at eye opening, neurons responding to similar visual features were not yet preferentially connected, indicating that the emergence of feature selectivity does not depend on the precise arrangement of local synaptic connections. After eye opening, local connectivity reorganized extensively: more connections formed selectively between neurons with similar visual responses and connections were eliminated between visually unresponsive neurons, but the overall connectivity rate did not change.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [
"10.1523/JNEUROSCI.0875-14.2014"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-d12ad470ec04"
]
- source_span
Although neural responses were already highly selective for visual stimuli at eye opening, neurons responding to similar visual features were not yet preferentially connected, indicating that the emergence of feature selectivity does not depend on the precise arrangement of local synaptic connections. After eye opening, local connectivity reorganized extensively: more connections formed selectively between neurons w...
- evidence_refs
[
{
"ref": "paper:paper-d12ad470ec04"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}