Version history

{
  "scope": "mouse, GE postmitotic precursors (E13.5/E14.5)",
  "claim_text": "A second postmitotic GE branch (precursor state 2) expresses canonical projection-neuron marker genes and is enriched in LGE-derived cells, distinguishing the LGE-derived projection neuron lineage (e.g., medium spiny neuron precursors) from interneuron precursor states (state 1) that express Arx and Maf — formalizing the dichotomy between LGE-derived projection neurons and CGE/MGE-derived cortical interneurons.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nature25999",
    "claim": "A second postmitotic GE branch (precursor state 2) expresses canonical projection-neuron marker genes and is enriched in LGE-derived cells, distinguishing the LGE-derived projection neuron lineage (e.g., medium spiny neuron precursors) from interneuron precursor states (state 1) that express Arx and Maf — formalizing the dichotomy between LGE-derived projection neurons and CGE/MGE-derived cortical interneurons.",
    "title": null,
    "cite_key": "Mayer2018",
    "evidence": "Branched expression-trajectory analysis of Drop-seq data; cross-validation with Lhx6-GFP-positive (MGE) vs Lhx6-GFP-negative (CGE+LGE) datasets and 10x Genomics replication.",
    "effect_size": "2 distinct postmitotic precursor states: state 1 (interneuron, Arx+/Maf+) and state 2 (projection neuron)",
    "figure_data": [],
    "text_access": "fulltext",
    "study_system": "mouse, GE postmitotic precursors (E13.5/E14.5)",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "primary",
    "_source_cluster_index": 116,
    "claim_source_sentence": "Arx, Maf; Fig. 3E ; Supplementary Table 4 ), whereas a second group of branches (i.e. precursor state 2) expressed known projection neuron marker genes (i.e.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Arx, Maf; Fig. 3E ; Supplementary Table 4 ), whereas a second group of branches (i.e. precursor state 2) expressed known projection neuron marker genes (i.e."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "2 distinct postmitotic precursor states: state 1 (interneuron, Arx+/Maf+) and state 2 (projection neuron)",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-c3e9fd7af6d3"
  ],
  "source_span": "Arx, Maf; Fig. 3E ; Supplementary Table 4 ), whereas a second group of branches (i.e. precursor state 2) expressed known projection neuron marker genes (i.e.",
  "study_system": "mouse, GE postmitotic precursors (E13.5/E14.5)",
  "evidence_refs": [
    {
      "ref": "paper:paper-c3e9fd7af6d3"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Branched expression-trajectory analysis of Drop-seq data; cross-validation with Lhx6-GFP-positive (MGE) vs Lhx6-GFP-negative (CGE+LGE) datasets and 10x Genomics replication.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "primary",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}