Details
- scope
- mouse, GE postmitotic precursors (E13.5/E14.5)
- section_id
- section_03
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
- effect_size
- 2 distinct postmitotic precursor states: state 1 (interneuron, Arx+/Maf+) and state 2 (projection neuron)
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-03-development
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- Arx, Maf; Fig. 3E ; Supplementary Table 4 ), whereas a second group of branches (i.e. precursor state 2) expressed known projection neuron marker genes (i.e.
- study_system
- mouse, GE postmitotic precursors (E13.5/E14.5)
- section_title
- Developmental Origins and Postnatal Maturation
- evidence_summary
- Branched expression-trajectory analysis of Drop-seq data; cross-validation with Lhx6-GFP-positive (MGE) vs Lhx6-GFP-negative (CGE+LGE) datasets and 10x Genomics replication.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- primary
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-03-development
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
A second postmitotic GE branch (precursor state 2) expresses canonical projection-neuron marker genes and is enriched in LGE-derived cells, distinguishing the LGE-derived projection neuron lineage (e.g., medium spiny neuron precursors) from interneuron precursor states (state 1) that express Arx and Maf — formalizing the dichotomy between LGE-derived projection neurons and CGE/MGE-derived cortical interneurons.
- raw_fields
{ "n": null, "doi": "10.1038/nature25999", "claim": "A second postmitotic GE branch (precursor state 2) expresses canonical projection-neuron marker genes and is enriched in LGE-derived cells, distinguishing the LGE-derived projection neuron lineage (e.g., medium spiny neuron precursors) from interneuron precursor states (state 1) that express Arx and Maf — formalizing the dichotomy between LGE-derived projection neurons and CGE/MGE-derived cortical interneurons.", "title": null, "cite_key": "Mayer2018", "evidence": "Branched expression-trajectory analysis of Drop-seq data; cross-validation with Lhx6-GFP-positive (MGE) vs Lhx6-GFP-negative (CGE+LGE) datasets and 10x Genomics replication.", "effect_size": "2 distinct postmitotic precursor states: state 1 (interneuron, Arx+/Maf+) and state 2 (projection neuron)", "figure_data": [], "text_access": "fulltext", "study_system": "mouse, GE postmitotic precursors (E13.5/E14.5)", "_source_cluster": "cluster_02_development_lineage", "replication_status": "primary", "_source_cluster_index": 116, "claim_source_sentence": "Arx, Maf; Fig. 3E ; Supplementary Table 4 ), whereas a second group of branches (i.e. precursor state 2) expressed known projection neuron marker genes (i.e.", "replication_evidence_dois": [], "effect_size_source_sentence": "Arx, Maf; Fig. 3E ; Supplementary Table 4 ), whereas a second group of branches (i.e. precursor state 2) expressed known projection neuron marker genes (i.e." }- source_refs
[ "paper:paper-c3e9fd7af6d3" ]
- evidence_refs
[ { "ref": "paper:paper-c3e9fd7af6d3" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }