Version history

{
  "scope": "adult mouse cortex, anterograde axonal tracing of M2 L5 IT Tlx3-Cre neurons + retrograde labeling + MouseLight single-axon reconstructions",
  "claim_text": "Mouse M2 layer-5 intratelencephalic (IT) Tlx3 neurons innervate L1 versus L2/3 of target cortices in a target-area-specific manner: uniform L1/L2/3 in local M2 but preferentially L1 in ipsilateral M1, S1 and AUD, with similar preferences in contralateral hemispheres.",
  "raw_fields": {
    "n": 3,
    "doi": "10.1093/cercor/bhac052",
    "claim": "Mouse M2 layer-5 intratelencephalic (IT) Tlx3 neurons innervate L1 versus L2/3 of target cortices in a target-area-specific manner: uniform L1/L2/3 in local M2 but preferentially L1 in ipsilateral M1, S1 and AUD, with similar preferences in contralateral hemispheres.",
    "cite_key": "Im2022",
    "evidence": "Anterograde tracing with synaptophysin-EGFP from M2 L5 Tlx3-Cre IT neurons; manual puncta counting across L1 and matched-thickness L2/3 (128 ± 26 μm) in multiple target cortical regions; complemented with MouseLight single-axon reconstructions.",
    "effect_size": "L1-bias index 0.53–0.66 in distal cortical targets vs. ~0 in local M2; paired-test contra vs ipsi non-significant.",
    "text_access": "fulltext",
    "study_system": "adult mouse cortex, anterograde axonal tracing of M2 L5 IT Tlx3-Cre neurons + retrograde labeling + MouseLight single-axon reconstructions",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "M2-Tlx3 cells uniformly innervated L1 and L2/3 in local M2 (index = −0.0022 ± 0.027, 3 mice, = 0.90, one sample-test, hypothetical value = 0), but preferentially L1 in ipsilateral M1 (index = 0.53 ± 0.15; = 0.024), ipsilateral S1 (index = 0.60 ± 0.15; = 0.020), ipsilateral AUD (index = 0.66 ± 0.16; = 0.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1038/nn1891",
      "10.1038/nature07709"
    ],
    "effect_size_source_sentence": "M2-Tlx3 cells uniformly innervated L1 and L2/3 in local M2 (index = −0.0022 ± 0.027, 3 mice, = 0.90, one sample-test, hypothetical value = 0), but preferentially L1 in ipsilateral M1 (index = 0.53 ± 0.15; = 0.024), ipsilateral S1 (index = 0.60 ± 0.15; = 0.020), ipsilateral AUD (index = 0.66 ± 0.16; = 0."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "L1-bias index 0.53–0.66 in distal cortical targets vs. ~0 in local M2; paired-test contra vs ipsi non-significant.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-e55711a2961a"
  ],
  "source_span": "M2-Tlx3 cells uniformly innervated L1 and L2/3 in local M2 (index = −0.0022 ± 0.027, 3 mice, = 0.90, one sample-test, hypothetical value = 0), but preferentially L1 in ipsilateral M1 (index = 0.53 ± 0.15; = 0.024), ipsilateral S1 (index = 0.60 ± 0.15; = 0.020), ipsilateral AUD (index = 0.66 ± 0.16; = 0.",
  "study_system": "adult mouse cortex, anterograde axonal tracing of M2 L5 IT Tlx3-Cre neurons + retrograde labeling + MouseLight single-axon reconstructions",
  "evidence_refs": [
    {
      "ref": "paper:paper-e55711a2961a"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Anterograde tracing with synaptophysin-EGFP from M2 L5 Tlx3-Cre IT neurons; manual puncta counting across L1 and matched-thickness L2/3 (128 ± 26 μm) in multiple target cortical regions; complemented with MouseLight single-axon reconstructions.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}