In adult mouse motor cortex, post-learning sleep produces a net decrease in spi…

In adult mouse motor cortex, post-learning sleep produces a net decrease in spine-surface GluA1-containing AMPA receptors while preserving the relative advantage of spines most potentiated by learning, consistent with synaptic down-selection.

{
  "n": 0,
  "doi": "10.1038/s41467-021-23156-2",
  "claim": "In adult mouse motor cortex, post-learning sleep produces a net decrease in spine-surface GluA1-containing AMPA receptors while preserving the relative advantage of spines most potentiated by learning, consistent with synaptic down-selection.",
  "cite_key": "Miyamoto2021",
  "evidence": "Repeated two-photon spine tracking with a GluA1-AMPAR marker after a sleep-dependent motor task showed sleep-induced global GluA1 reduction; spines with the largest learning-induced GluA1 gains gained a relative advantage after sleep.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Adult mouse motor cortex pyramidal-neuron spines, in vivo two-photon imaging of GluA1",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "In mouse motor cortex, sleep leads to an overall net decrease in spine-surface GluA1-containing AMPA receptors, both before and after learning.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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