Version history

{
  "scope": "mouse hippocampus CA1, VIP-eGFP, acute slices, adult",
  "claim_text": "In adult mouse CA1, hippocampal type-3 interneuron-specific (I-S3) VIP+/CR+ cells have very high input resistance (~500 MΩ) and a slow membrane time constant (~36 ms), values that are unchanged in VIP-Tg amyloid-overexpressing animals despite firing-rate deficits.",
  "raw_fields": {
    "n": 7,
    "doi": "10.7554/elife.95412",
    "claim": "In adult mouse CA1, hippocampal type-3 interneuron-specific (I-S3) VIP+/CR+ cells have very high input resistance (~500 MΩ) and a slow membrane time constant (~36 ms), values that are unchanged in VIP-Tg amyloid-overexpressing animals despite firing-rate deficits.",
    "title": null,
    "cite_key": "Michaud2024",
    "evidence": "targeted whole-cell patch-clamp from VIP-eGFP/VIP-Tg+ I-S3 cells in adult mouse CA1 acute slices",
    "effect_size": "VIP-nonTg I-S3: Vrest −60.5 ± 1.7 mV, Rin 517 ± 37 MΩ, Cm 32.8 ± 3.5 pF, τm 36.5 ± 3.2 ms (n=7 cells/5 animals)",
    "text_access": "fulltext",
    "study_system": "mouse hippocampus CA1, VIP-eGFP, acute slices, adult",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replicated",
    "_source_cluster_index": 6,
    "claim_source_sentence": "Notably, the resting membrane potential, input resistance, membrane capacitance, and membrane time constant of I-S3 cells showed no significant differences between VIP-nonTg (−60.5 ± 1.7 mV, 517 ± 37 MΩ, 32.8 ± 3.5 pF, 36.5 ± 3.2 ms) and VIP-Tg mice (−65.8 ± 2.1 mV, 493 ± 45 MΩ, 29.3 ± 2.9 pF, 35.7",
    "replication_evidence_dois": [
      "10.1093/cercor/bhz334",
      "10.1523/jneurosci.2063-17.2018"
    ],
    "effect_size_source_sentence": "Notably, the resting membrane potential, input resistance, membrane capacitance, and membrane time constant of I-S3 cells showed no significant differences between VIP-nonTg (−60.5 ± 1.7 mV, 517 ± 37 MΩ, 32.8 ± 3.5 pF, 36.5 ± 3.2 ms) and VIP-Tg mice (−65.8 ± 2.1 mV, 493 ± 45 MΩ, 29.3 ± 2.9 pF, 35.7"
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "VIP-nonTg I-S3: Vrest −60.5 ± 1.7 mV, Rin 517 ± 37 MΩ, Cm 32.8 ± 3.5 pF, τm 36.5 ± 3.2 ms (n=7 cells/5 animals)",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-244a49e02ebb"
  ],
  "source_span": "Notably, the resting membrane potential, input resistance, membrane capacitance, and membrane time constant of I-S3 cells showed no significant differences between VIP-nonTg (−60.5 ± 1.7 mV, 517 ± 37 MΩ, 32.8 ± 3.5 pF, 36.5 ± 3.2 ms) and VIP-Tg mice (−65.8 ± 2.1 mV, 493 ± 45 MΩ, 29.3 ± 2.9 pF, 35.7",
  "study_system": "mouse hippocampus CA1, VIP-eGFP, acute slices, adult",
  "evidence_refs": [
    {
      "ref": "paper:paper-244a49e02ebb"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "targeted whole-cell patch-clamp from VIP-eGFP/VIP-Tg+ I-S3 cells in adult mouse CA1 acute slices",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}