Details
- scope
- mouse hippocampus CA1, VIP-eGFP, acute slices, adult
- section_id
- section_05
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- effect_size
- VIP-nonTg I-S3: Vrest −60.5 ± 1.7 mV, Rin 517 ± 37 MΩ, Cm 32.8 ± 3.5 pF, τm 36.5 ± 3.2 ms (n=7 cells/5 animals)
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- source_kind
- review_finding
- source_path
- evidence/section_05_evidence_package.json
- study_system
- mouse hippocampus CA1, VIP-eGFP, acute slices, adult
- section_title
- Intrinsic Electrophysiology
- evidence_summary
- targeted whole-cell patch-clamp from VIP-eGFP/VIP-Tg+ I-S3 cells in adult mouse CA1 acute slices
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (6)
- claim_text
In adult mouse CA1, hippocampal type-3 interneuron-specific (I-S3) VIP+/CR+ cells have very high input resistance (~500 MΩ) and a slow membrane time constant (~36 ms), values that are unchanged in VIP-Tg amyloid-overexpressing animals despite firing-rate deficits.
- raw_fields
{ "n": 7, "doi": "10.7554/elife.95412", "claim": "In adult mouse CA1, hippocampal type-3 interneuron-specific (I-S3) VIP+/CR+ cells have very high input resistance (~500 MΩ) and a slow membrane time constant (~36 ms), values that are unchanged in VIP-Tg amyloid-overexpressing animals despite firing-rate deficits.", "title": null, "cite_key": "Michaud2024", "evidence": "targeted whole-cell patch-clamp from VIP-eGFP/VIP-Tg+ I-S3 cells in adult mouse CA1 acute slices", "effect_size": "VIP-nonTg I-S3: Vrest −60.5 ± 1.7 mV, Rin 517 ± 37 MΩ, Cm 32.8 ± 3.5 pF, τm 36.5 ± 3.2 ms (n=7 cells/5 animals)", "text_access": "fulltext", "study_system": "mouse hippocampus CA1, VIP-eGFP, acute slices, adult", "_source_cluster": "cluster_04_intrinsic_electrophysiology", "replication_status": "replicated", "_source_cluster_index": 6, "claim_source_sentence": "Notably, the resting membrane potential, input resistance, membrane capacitance, and membrane time constant of I-S3 cells showed no significant differences between VIP-nonTg (−60.5 ± 1.7 mV, 517 ± 37 MΩ, 32.8 ± 3.5 pF, 36.5 ± 3.2 ms) and VIP-Tg mice (−65.8 ± 2.1 mV, 493 ± 45 MΩ, 29.3 ± 2.9 pF, 35.7", "replication_evidence_dois": [ "10.1093/cercor/bhz334", "10.1523/jneurosci.2063-17.2018" ], "effect_size_source_sentence": "Notably, the resting membrane potential, input resistance, membrane capacitance, and membrane time constant of I-S3 cells showed no significant differences between VIP-nonTg (−60.5 ± 1.7 mV, 517 ± 37 MΩ, 32.8 ± 3.5 pF, 36.5 ± 3.2 ms) and VIP-Tg mice (−65.8 ± 2.1 mV, 493 ± 45 MΩ, 29.3 ± 2.9 pF, 35.7" }- source_refs
[ "paper:paper-244a49e02ebb" ]
- source_span
Notably, the resting membrane potential, input resistance, membrane capacitance, and membrane time constant of I-S3 cells showed no significant differences between VIP-nonTg (−60.5 ± 1.7 mV, 517 ± 37 MΩ, 32.8 ± 3.5 pF, 36.5 ± 3.2 ms) and VIP-Tg mice (−65.8 ± 2.1 mV, 493 ± 45 MΩ, 29.3 ± 2.9 pF, 35.7
- evidence_refs
[ { "ref": "paper:paper-244a49e02ebb" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }