Version history

{
  "scope": "humans, advanced PD, prospective double-blind crossover study of STN vs GPi DBS",
  "claim_text": "In a double-blind crossover study in advanced PD, STN DBS produced a median 49% UPDRS-III improvement and GPi DBS a 37% improvement (both P<0.001), demonstrating that BG output nodes are the effective DBS targets.",
  "raw_fields": {
    "n": 134,
    "doi": "10.1056/nejmoa000827",
    "claim": "In a double-blind crossover study in advanced PD, STN DBS produced a median 49% UPDRS-III improvement and GPi DBS a 37% improvement (both P<0.001), demonstrating that BG output nodes are the effective DBS targets.",
    "cite_key": "Obeso2001",
    "evidence": "",
    "effect_size": "STN DBS: median 49% UPDRS-III improvement; GPi DBS: 37%; both P<0.001",
    "text_access": "abstract_only",
    "study_system": "humans, advanced PD, prospective double-blind crossover study of STN vs GPi DBS",
    "source_cluster_id": "cluster_04",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Three months after the procedures were performed, double-blind, crossover evaluations demonstrated that stimulation of the subthalamic nucleus was associated with a median improvement in the motor score (as compared with no stimulation) of 49 percent, and stimulation of the pars interna of the globus pallidus with a median improvement of 37 percent (P<0.001 for both comparisons).",
    "replication_evidence_dois": [
      "10.1056/nejmoa060281"
    ],
    "effect_size_source_sentence": "Three months after the procedures were performed, double-blind, crossover evaluations demonstrated that stimulation of the subthalamic nucleus was associated with a median improvement in the motor score (as compared with no stimulation) of 49 percent, and stimulation of the pars interna of the globus pallidus with a median improvement of 37 percent (P<0.001 for both comparisons)."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "effect_size": "STN DBS: median 49% UPDRS-III improvement; GPi DBS: 37%; both P<0.001",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-04",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-e7b7890630b8"
  ],
  "source_span": "Three months after the procedures were performed, double-blind, crossover evaluations demonstrated that stimulation of the subthalamic nucleus was associated with a median improvement in the motor score (as compared with no stimulation) of 49 percent, and stimulation of the pars interna of the globus pallidus with a median improvement of 37 percent (P<0.001 for both comparisons).",
  "study_system": "humans, advanced PD, prospective double-blind crossover study of STN vs GPi DBS",
  "evidence_refs": [
    {
      "ref": "paper:paper-e7b7890630b8"
    }
  ],
  "section_title": "Striatal Output Pathways: Direct, Indirect, and Beyond",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-04",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}