Details
- scope
- humans, advanced PD, prospective double-blind crossover study of STN vs GPi DBS
- claim_text
- In a double-blind crossover study in advanced PD, STN DBS produced a median 49% UPDRS-III improvement and GPi DBS a 37% improvement (both P<0.001), demonstrating that BG output nodes are the effective DBS targets.
- section_id
- section_04
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
- effect_size
- STN DBS: median 49% UPDRS-III improvement; GPi DBS: 37%; both P<0.001
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-04
- source_kind
- review_finding
- source_path
- evidence/section_04_evidence_package.json
- study_system
- humans, advanced PD, prospective double-blind crossover study of STN vs GPi DBS
- section_title
- Striatal Output Pathways: Direct, Indirect, and Beyond
- evidence_summary
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-04
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (5)
- raw_fields
{ "n": 134, "doi": "10.1056/nejmoa000827", "claim": "In a double-blind crossover study in advanced PD, STN DBS produced a median 49% UPDRS-III improvement and GPi DBS a 37% improvement (both P<0.001), demonstrating that BG output nodes are the effective DBS targets.", "cite_key": "Obeso2001", "evidence": "", "effect_size": "STN DBS: median 49% UPDRS-III improvement; GPi DBS: 37%; both P<0.001", "text_access": "abstract_only", "study_system": "humans, advanced PD, prospective double-blind crossover study of STN vs GPi DBS", "source_cluster_id": "cluster_04", "replication_status": "independently_replicated", "claim_source_sentence": "Three months after the procedures were performed, double-blind, crossover evaluations demonstrated that stimulation of the subthalamic nucleus was associated with a median improvement in the motor score (as compared with no stimulation) of 49 percent, and stimulation of the pars interna of the globus pallidus with a median improvement of 37 percent (P<0.001 for both comparisons).", "replication_evidence_dois": [ "10.1056/nejmoa060281" ], "effect_size_source_sentence": "Three months after the procedures were performed, double-blind, crossover evaluations demonstrated that stimulation of the subthalamic nucleus was associated with a median improvement in the motor score (as compared with no stimulation) of 49 percent, and stimulation of the pars interna of the globus pallidus with a median improvement of 37 percent (P<0.001 for both comparisons)." }- source_refs
[ "paper:paper-e7b7890630b8" ]
- source_span
Three months after the procedures were performed, double-blind, crossover evaluations demonstrated that stimulation of the subthalamic nucleus was associated with a median improvement in the motor score (as compared with no stimulation) of 49 percent, and stimulation of the pars interna of the globus pallidus with a median improvement of 37 percent (P<0.001 for both comparisons).
- evidence_refs
[ { "ref": "paper:paper-e7b7890630b8" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }