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- Live5/17/2026, 4:35:28 PM
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{ "scope": "rat/mouse hippocampus CA1 and CA3, in vivo", "claim_text": "Axo-axonic cells are inhibited during sharp-wave ripples while PV basket cells strongly increase firing, demonstrating distinct roles of PV+ subtypes in hippocampal network states", "raw_fields": { "n": 0, "doi": "10.1098/rstb.2012.0518", "claim": "Axo-axonic cells are inhibited during sharp-wave ripples while PV basket cells strongly increase firing, demonstrating distinct roles of PV+ subtypes in hippocampal network states", "evidence": "Axo-axonic cells are inhibited during sharp-wave ripples while PV basket cells strongly increase firing, demonstrating distinct roles of PV+ subtypes in hippocampal network states", "effect_size": "Axo-axonic cells are inhibited during sharp-wave ripples while PV basket cells strongly increase firing, demonstrating distinct roles of PV+ subtypes in hippocampal network states", "text_access": "fulltext", "study_system": "rat/mouse hippocampus CA1 and CA3, in vivo", "replication_status": "independently_replicated", "claim_source_sentence": "Axo-axonic cells are inhibited during SWRs, when many pyramidal cells fire synchronously. This dual inverse correlation demonstrates the key inhibitory role of axo-axonic cells. Parvalbumin-expressing basket cells fire phase locked to field gamma activity in both CA1 and CA3, and also strongly increase firing during SWRs, together with dendrite-innervating bistratified cells, phasing pyramidal cell discharge.", "replication_evidence_dois": [ "10.1523/jneurosci.4104-10.2010", "10.1073/pnas.1210929109" ], "effect_size_source_sentence": "Axo-axonic cells are inhibited during SWRs, when many pyramidal cells fire synchronously. This dual inverse correlation demonstrates the key inhibitory role of axo-axonic cells. Parvalbumin-expressing basket cells fire phase locked to field gamma activity in both CA1 and CA3, and also strongly increase firing during SWRs, together with dendrite-innervating bistratified cells, phasing pyramidal cell discharge." }, "section_id": "section_09_evidence_package", "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json", "effect_size": "Axo-axonic cells are inhibited during sharp-wave ripples while PV basket cells strongly increase firing, demonstrating distinct roles of PV+ subtypes in hippocampal network states", "review_repo": "ComputationalReviewPV", "section_ref": "wiki_page:computationalreviewpv-09", "source_kind": "review_finding", "source_path": "evidence/section_09_evidence_package.json", "source_refs": [ "paper:paper-12b8963c5eea" ], "source_span": "Axo-axonic cells are inhibited during SWRs, when many pyramidal cells fire synchronously. This dual inverse correlation demonstrates the key inhibitory role of axo-axonic cells. Parvalbumin-expressing basket cells fire phase locked to field gamma activity in both CA1 and CA3, and also strongly increase firing during SWRs, together with dendrite-innervating bistratified cells, phasing pyramidal cell discharge.", "study_system": "rat/mouse hippocampus CA1 and CA3, in vivo", "evidence_refs": [ { "ref": "paper:paper-12b8963c5eea" } ], "section_title": "Brain Region and Layer Context: Beyond Primary Sensory Cortex", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }, "evidence_summary": "Axo-axonic cells are inhibited during sharp-wave ripples while PV basket cells strongly increase firing, demonstrating distinct roles of PV+ subtypes in hippocampal network states", "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7", "replication_status": "independently_replicated", "review_package_ref": "analysis_bundle:ab-e6261c8263e7", "source_artifact_ref": "wiki_page:computationalreviewpv-09", "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_09_evidence_package.json", "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "created_by": "persona-jerome-lecoq-gbo-neuroscience", "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }