- claim_text
In behavioural variant frontotemporal dementia, TDP-43 pathology in von Economo neurons and fork cells of the right frontoinsular cortex is associated with atrophy throughout the salience network and with empathy loss, linking neuron-type-specific pathobiology to large-scale network degeneration.
- raw_fields
{
"n": 0,
"doi": "10.1093/cercor/bhaa119",
"claim": "In behavioural variant frontotemporal dementia, TDP-43 pathology in von Economo neurons and fork cells of the right frontoinsular cortex is associated with atrophy throughout the salience network and with empathy loss, linking neuron-type-specific pathobiology to large-scale network degeneration.",
"cite_key": "Pasquini2020",
"evidence": "In behavioural variant frontotemporal dementia, TDP-43 pathology in von Economo neurons and fork cells of the right frontoinsular cortex is associated with atrophy throughout the salience network and with empathy loss, linking neuron-type-specific pathobiology to large-scale network degeneration.",
"effect_size": "43",
"text_access": "abstract_only",
"study_system": "16 patients spanning bvFTD/ALS; structural MRI plus quantitative histopathology",
"source_cluster_id": "cluster_07",
"replication_status": "replication_unknown",
"claim_source_sentence": "Our goal was to determine how neuron type-specific TAR DNA-binding protein of 43 kDa (TDP-43) pathobiology relates to atrophy in specific brain structures and to loss of emotional empathy, a cardinal feature of bvFTD.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "In behavioural variant frontotemporal dementia, TDP-43 pathology in von Economo neurons and fork cells of the right frontoinsular cortex is associated with atrophy throughout the salience network and with empathy loss, linking neuron-type-specific pathobiology to large-scale network degeneration."
}- source_refs
[
"paper:paper-53c3bac800a8"
]
- evidence_refs
[
{
"ref": "paper:paper-53c3bac800a8"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}- evidence_summary
In behavioural variant frontotemporal dementia, TDP-43 pathology in von Economo neurons and fork cells of the right frontoinsular cortex is associated with atrophy throughout the salience network and with empathy loss, linking neuron-type-specific pathobiology to large-scale network degeneration.