Version history

{
  "scope": "16 patients spanning bvFTD/ALS; structural MRI plus quantitative histopathology",
  "claim_text": "In behavioural variant frontotemporal dementia, TDP-43 pathology in von Economo neurons and fork cells of the right frontoinsular cortex is associated with atrophy throughout the salience network and with empathy loss, linking neuron-type-specific pathobiology to large-scale network degeneration.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1093/cercor/bhaa119",
    "claim": "In behavioural variant frontotemporal dementia, TDP-43 pathology in von Economo neurons and fork cells of the right frontoinsular cortex is associated with atrophy throughout the salience network and with empathy loss, linking neuron-type-specific pathobiology to large-scale network degeneration.",
    "cite_key": "Pasquini2020",
    "evidence": "In behavioural variant frontotemporal dementia, TDP-43 pathology in von Economo neurons and fork cells of the right frontoinsular cortex is associated with atrophy throughout the salience network and with empathy loss, linking neuron-type-specific pathobiology to large-scale network degeneration.",
    "effect_size": "43",
    "text_access": "abstract_only",
    "study_system": "16 patients spanning bvFTD/ALS; structural MRI plus quantitative histopathology",
    "source_cluster_id": "cluster_07",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Our goal was to determine how neuron type-specific TAR DNA-binding protein of 43 kDa (TDP-43) pathobiology relates to atrophy in specific brain structures and to loss of emotional empathy, a cardinal feature of bvFTD.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "In behavioural variant frontotemporal dementia, TDP-43 pathology in von Economo neurons and fork cells of the right frontoinsular cortex is associated with atrophy throughout the salience network and with empathy loss, linking neuron-type-specific pathobiology to large-scale network degeneration."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_08_evidence_package.json",
  "effect_size": "43",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-08",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-53c3bac800a8"
  ],
  "source_span": "Our goal was to determine how neuron type-specific TAR DNA-binding protein of 43 kDa (TDP-43) pathobiology relates to atrophy in specific brain structures and to loss of emotional empathy, a cardinal feature of bvFTD.",
  "study_system": "16 patients spanning bvFTD/ALS; structural MRI plus quantitative histopathology",
  "evidence_refs": [
    {
      "ref": "paper:paper-53c3bac800a8"
    }
  ],
  "section_title": "Cortical Association Connectome: Intra-Cortical Loops and Modules",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "In behavioural variant frontotemporal dementia, TDP-43 pathology in von Economo neurons and fork cells of the right frontoinsular cortex is associated with atrophy throughout the salience network and with empathy loss, linking neuron-type-specific pathobiology to large-scale network degeneration.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-08",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_08_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}