Details
- scope
- primate and human movement disorders
- claim_text
- A two-pathway model in which D1-direct and D2-indirect striatal output have opposite influence on basal ganglia output explains hyperkinetic and hypokinetic movement disorders
- section_id
- section_05
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_05_evidence_package.json
- effect_size
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-05
- source_kind
- review_finding
- source_path
- evidence/section_05_evidence_package.json
- source_span
- Hyperkinetic disorders, which are characterized by an excess of abnormal movements, are postulated to result from the selective impairment of striatal neurons projecting to the lateral globus pallidus.
- study_system
- primate and human movement disorders
- section_title
- Pallidal Organization and the Disinhibition Principle
- evidence_summary
- Theoretical synthesis linking striatal projection-neuron subpopulations to clinical movement-disorder phenotypes
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- contested
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-05
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_05_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1016/0166-2236(89)90074-x", "claim": "A two-pathway model in which D1-direct and D2-indirect striatal output have opposite influence on basal ganglia output explains hyperkinetic and hypokinetic movement disorders", "cite_key": "Albin1989", "evidence": "Theoretical synthesis linking striatal projection-neuron subpopulations to clinical movement-disorder phenotypes", "effect_size": "", "text_access": "abstract_only", "study_system": "primate and human movement disorders", "source_cluster_id": "cluster_04", "replication_status": "contested", "claim_source_sentence": "Hyperkinetic disorders, which are characterized by an excess of abnormal movements, are postulated to result from the selective impairment of striatal neurons projecting to the lateral globus pallidus.", "replication_evidence_dois": [ "10.1016/0165-0173(94)00008-d", "10.1038/nature11846" ], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-7b10b6c4b845" ]
- evidence_refs
[ { "ref": "paper:paper-7b10b6c4b845" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }