- claim_text
The classical functional anatomy model of basal ganglia disorders proposes that hyperkinetic disorders result from selective impairment of striatal neurons projecting to the lateral globus pallidus (indirect pathway), while hypokinetic disorders like Parkinson's involve increased basal ganglia output.
- raw_fields
{
"n": 0,
"doi": "10.1016/0166-2236(89)90074-x",
"claim": "The classical functional anatomy model of basal ganglia disorders proposes that hyperkinetic disorders result from selective impairment of striatal neurons projecting to the lateral globus pallidus (indirect pathway), while hypokinetic disorders like Parkinson's involve increased basal ganglia output.",
"cite_key": "Albin1989",
"evidence": "Synthesis of experimental animal and post-mortem human data establishing the direct/indirect pathway scheme that anchored basal ganglia models within each parallel circuit.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "human and animal basal ganglia synthesis",
"source_cluster_id": "cluster_06",
"replication_status": "independently_replicated",
"claim_source_sentence": "Hyperkinetic disorders, which are characterized by an excess of abnormal movements, are postulated to result from the selective impairment of striatal neurons projecting to the lateral globus pallidus.",
"replication_evidence_dois": [
"10.1016/0166-2236(90)90107-l",
"10.1101/cshperspect.a009621"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-7b10b6c4b845"
]
- evidence_refs
[
{
"ref": "paper:paper-7b10b6c4b845"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}