Version history

{
  "scope": "mouse (Mus musculus); cortico-basal ganglia-thalamocortical circuit",
  "claim_text": "In rodents, an 'open' cortico-basal ganglia loop allows limbic information from the ventral striatum to modulate motor cortex via a nigrothalamic pathway, demonstrating that the canonical parallel-loops architecture is not strictly closed.",
  "raw_fields": {
    "n": null,
    "doi": "10.7554/elife.49995",
    "claim": "In rodents, an 'open' cortico-basal ganglia loop allows limbic information from the ventral striatum to modulate motor cortex via a nigrothalamic pathway, demonstrating that the canonical parallel-loops architecture is not strictly closed.",
    "cite_key": "Aoki2019",
    "evidence": "Combined viral tracing, slice electrophysiology, and in vivo optogenetics of vStr→SNr→motor thalamus→M1 pathway in mice.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "mouse (Mus musculus); cortico-basal ganglia-thalamocortical circuit",
    "source_cluster_id": "cluster_01",
    "replication_status": "single-study",
    "claim_source_sentence": "While our data do demonstrate mostly closed corticobasal ganglia loops within each domain, our results confirm an open cortico-basal ganglia loop allowing a one-way interaction from limbic to motor circuitry (Figure 5U).",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_01",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_01_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-01",
  "source_kind": "review_finding",
  "source_path": "evidence/section_01_evidence_package.json",
  "source_refs": [
    "paper:paper-3023485dbad7"
  ],
  "source_span": "While our data do demonstrate mostly closed corticobasal ganglia loops within each domain, our results confirm an open cortico-basal ganglia loop allowing a one-way interaction from limbic to motor circuitry (Figure 5U).",
  "study_system": "mouse (Mus musculus); cortico-basal ganglia-thalamocortical circuit",
  "evidence_refs": [
    {
      "ref": "paper:paper-3023485dbad7"
    }
  ],
  "section_title": "Introduction: Swanson's Loop Hypothesis and Its Intellectual Lineage",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Combined viral tracing, slice electrophysiology, and in vivo optogenetics of vStr→SNr→motor thalamus→M1 pathway in mice.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-01",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_01_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}